Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.

UVI 3003 [847239-17-2]

Afdrukken

Referentie NB-64-08146-5mg

Formaat : 5mg

Merk : Neo Biotech

Meer informatie aanvragen

Remove All

UVI 3003

Copy Product Info

Synonyms:

Catalog No. T17209 Copy Product Info

Purity: 99.82%

UVI 3003 is a highly selective antagonist of the retinoid X receptor, inhibiting Xenopus and human RXRα in Cos7 cells with IC50 values of 0.22 μM and 0.24 μM, respectively.

Cas No. 847239-17-2

For research use only—not for human use. No sales to individuals. Use as intended only.

Select Batch

Purity:99.82%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	UVI 3003 is a highly selective antagonist of the retinoid X receptor, inhibiting Xenopus and human RXRα in Cos7 cells with IC50 values of 0.22 μM and 0.24 μM, respectively.
Targets & IC50	RXRα:0.24 μM(Human RXRα, in Cos7 cells), RXRα:0.22 μM(Xenopus RXRα, in Cos7 cells)
In vitro	UVI3003 fully activates xPPARγ (EC50: 12.6 μM) and is almost completely inactive on hPPARγ and mPPARγ. UVI 3003 causes a 65.4% difference in EECD34 cell fusion and desmin expression. UVI 3003 (10 μM) does not change the proliferation rate of extraocular muscles (EOM)-derived or LEG-derived EECD34 cells [1][2].

Chemical Properties

Molecular Weight	436.58
Formula	C₂₈H₃₆O₄
Cas No.	847239-17-2
Smiles	CCCCCOc1cc2c(cc1-c1cc(\C=C\C(O)=O)ccc1O)C(C)(C)CCC2(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (343.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (22.91 mM), Solution.

10% DMSO+90% Saline: < 10 mg/mL (22.91 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2905 mL	11.4527 mL	22.9053 mL	114.5265 mL
5 mM	0.4581 mL	2.2905 mL	4.5811 mL	22.9053 mL
10 mM	0.2291 mL	1.1453 mL	2.2905 mL	11.4527 mL
20 mM	0.1145 mL	0.5726 mL	1.1453 mL	5.7263 mL
50 mM	0.0458 mL	0.2291 mL	0.4581 mL	2.2905 mL
100 mM	0.0229 mL	0.1145 mL	0.2291 mL	1.1453 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Xenopus RXRα, in Cos7 cellsUVI-3003UVI3003UVI 3003RXRαRetinoidReceptorRetinoid X receptorsRetinoid ReceptorRetinoic acid receptorsRAR/RXRInhibitorinhibitHuman RXRα, in Cos7 cellsAutophagy

Related Tags: UVI 3003 chemical structure | UVI 3003 in vitro | UVI 3003 formula | UVI 3003 molecular weight