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Valencene [4630-07-3]

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Referentie NB-64-08154-100mg

Formaat : 100mg

Merk : Neo Biotech

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Valencene (Synonyms: NSC-148969, NSC148969, NSC 148969)

Catalog No. T17214 Copy Product Info

Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene has anti-allergic, anti-inflammatory, anti-melanogenic, and antioxidant activities. Valencene inhibits the overexpression of Th2 chemokines and pro-inflammatory chemokines by blocking the NF-κB pathway.

Valencene

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Synonyms NSC-148969, NSC148969, NSC 148969

Cas No. 4630-07-3

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Batch Information

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Appearance:Liquid

Color:White

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COA HNMR HPLC

Product Introduction

Valencene AI Summary

Valencene shows bioactivity as an antagonist for TRPV1 and ORAI1 channels in HEK293T cells, leading to varying degrees of inhibition on capsaicin-induced currents. It inhibits store-operated calcium entry (SOCE) signaling in human Jurkat-T cells, resulting in reduced cytoplasmic calcium concentration. The compound also exhibits inhibitory effects on UV-induced melanogenesis in mouse B16F10 cells, reducing melanin levels. Moreover, it inhibits mushroom tyrosinase, which plays a role in melanin synthesis, as measured by spectrophotometry..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene has anti-allergic, anti-inflammatory, anti-melanogenic, and antioxidant activities. Valencene inhibits the overexpression of Th2 chemokines and pro-inflammatory chemokines by blocking the NF-κB pathway.
Synonyms	NSC-148969, NSC148969, NSC 148969

Chemical Properties

Molecular Weight	204.35
Formula	C₁₅H₂₄
Cas No.	4630-07-3
Smiles	C[C@@H]1CCC=C2CC[C@H](C[C@@]12C)C(C)=C
Relative Density.	0.89g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (293.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8936 mL	24.4678 mL	48.9356 mL	244.6782 mL
5 mM	0.9787 mL	4.8936 mL	9.7871 mL	48.9356 mL
10 mM	0.4894 mL	2.4468 mL	4.8936 mL	24.4678 mL
20 mM	0.2447 mL	1.2234 mL	2.4468 mL	12.2339 mL
50 mM	0.0979 mL	0.4894 mL	0.9787 mL	4.8936 mL
100 mM	0.0489 mL	0.2447 mL	0.4894 mL	2.4468 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.