Biological Activity

6-Hydroxydopamine hydrobromide is an antagonist of the neurotransmitter dopamine. It is a neurotoxin that disrupts catecholaminergic terminals. It is used in the study of Parkinson's disease (PD), attention deficit hyperactivity disorder (ADHD) and Leschner's syndrome.*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information

Molecular Weight	250.09
Formula	(HO)3C6H2CH2CH2NH2.HBr
CAS Number	636-00-0
Solubility (25°C)	DMSO ≥ 40 mg/mL
Storage	2-8°C, dry, sealed

References

[1] Chia-Yuan Lin, et al. Carnosic acid protects SH-SY5Y cells against 6-hydroxydopamine-induced cell death through upregulation of parkin pathway

[2] Hamdolah Sharifi, et al. The effect of chronic administration of buspirone on 6-hydroxydopamine-induced catalepsy in rats

[3] Alireza M Nayebi, et al. Buspirone improves 6-hydroxydopamine-induced catalepsy through stimulation of nigral 5-HT(1A) receptors in rats

[4] H Cambridge, et al. Investigation of 6-hydroxydopamine-induced plasma extravasation in rat skin

[5] D W Clark, et al. Long-lasting peripheral and central effects of 6-hydroxydopamine in rats