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> Anti-DOPA Decarboxylase Polyclonal Antibody

Anti-DOPA Decarboxylase Polyclonal Antibody

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Referentie NB-64-155236-100uL

Formaat : 100uL

Merk : Neo Biotech


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Anti-DOPA Decarboxylase Polyclonal Antibody

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Synonyms:

Catalog No. TMAB-05284 Copy Product Info
Anti-DOPA Decarboxylase Polyclonal Antibody is a Rabbit antibody targeting DOPA Decarboxylase. Anti-DOPA Decarboxylase Polyclonal Antibody can be used in WB.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-DOPA Decarboxylase Polyclonal Antibody is a Rabbit antibody targeting DOPA Decarboxylase. Anti-DOPA Decarboxylase Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Verified Activity
Sample:
Lane 1: Cerebrum (Mouse) Tissue Lysate at 40 μg
Lane 2: adrenal gland (Mouse) TissueLysate at 40 μg
Lane 3: Cerebrum (Rat) Tissue Lysate at 40 μg
Lane 4: adrenal gland (Rat) Tissue Lysate at 40 μg
Lane 5: SH-SY5Y (Human) Cell Lysate at 30 μg
Lane 6: HepG2 (Human) Cell Lysate at 30 μg
Lane 7: Jurkat (Human) Cell Lysate at 30 μg
Lane 8: A549 (Human) Cell Lysate at 30 μg
Primary: Anti-DOPA Decarboxylase (TMAB-05284) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 50 kD
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research Backgroundbs-0180P is one synthetic peptide derived from human DDC. DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human DDC
Antigen Species
Human
Gene Name
DDC
Gene ID
1644
Protein Name
Aromatic-L-amino-acid decarboxylase
Uniprot ID
P20711
Function
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Chemical Properties
Molecular WeightTheoretical: 53 kDa. Actual: 50 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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