C6 Blocking Peptide
Referentie MBS9624136-5x1mg
Formaat : 5x1mg
Merk : MyBiosource
C6 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9624136Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details
Product Overview
Online Datasheet in PDFProduct Name
C6, Blocking Peptide
Full Product Name
C6 Blocking Peptide
Product Gene Name
C6 blocking peptide
Product Synonym Names
AW111623; C6; CO6_HUMAN; Complement component 6; Complement component C6
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.
Purity/Purification
The purity is >90%,tested by HPLC and MS.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
C6 peptide (MBS9624136) is used for blocking the activity of C6 antibody (MBS9605419)
Molecular Weight
105 KD
Chromosome Location
Chromosome: 5; NC_000005.9 (41142336..41261540, complement). Location: 5p13
OMIM
217050
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Notes
For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for C6 blocking peptide
Blocking/Control
Related Product Information for C6 blocking peptide
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.
Other Notes
Small volumes of C6 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for C6 purchase
MBS9624136 is a blocking peptide targeting C6.
Additional Details
NCBI/Uniprot data below describe general gene information for C6. It may not necessarily be applicable to this product.
NCBI Official Full Name
complement component C6
NCBI Official Synonym Full Names
complement component 6
NCBI Official Symbol
C6
UniProt Protein Name
Complement component C6
Protein Family
Complement component
UniProt Gene Name
C6
UniProt Entry Name
CO6_HUMAN
NCBI Protein Information
complement component C6
NCBI Summary for C6
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Show more UniProt Comments for C6
C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 5p13
Cellular Component: membrane attack complex; extracellular region
Molecular Function: protein binding
Biological Process: positive regulation of angiogenesis; positive regulation of activation of membrane attack complex; in utero embryonic development; cytolysis; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation
Disease: Complement Component 6 Deficiency
Show more Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 5p13
Cellular Component: membrane attack complex; extracellular region
Molecular Function: protein binding
Biological Process: positive regulation of angiogenesis; positive regulation of activation of membrane attack complex; in utero embryonic development; cytolysis; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation
Disease: Complement Component 6 Deficiency
Research Articles on C6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with C6 blocking peptide
| Products by Pathway | Pathway Diagram |
|---|---|
| Complement Activation, Classical Pathway antibodies | Complement Activation, Classical Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement Cascade Pathway antibodies | Complement Cascade Pathway Diagram |
| Immune System Pathway antibodies | Immune System Pathway Diagram |
| Innate Immune System Pathway antibodies | Innate Immune System Pathway Diagram |
| Prion Diseases Pathway antibodies | Prion Diseases Pathway Diagram |
| Prion Diseases Pathway antibodies | Prion Diseases Pathway Diagram |
| Systemic Lupus Erythematosus Pathway antibodies | Systemic Lupus Erythematosus Pathway Diagram |
Diseases associated with C6 blocking peptide
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >3915 publications with C6 and Neoplasms |
| Nervous System Diseases Antibodies | >2937 publications with C6 and Nervous System Diseases |
| Brain Diseases Antibodies | >1430 publications with C6 and Brain Diseases |
| Necrosis Antibodies | >372 publications with C6 and Necrosis |
| Complement Component 6 Deficiency Antibodies | >301 publications with C6 and Complement Component 6 Deficiency |
| Immune System Diseases Antibodies | >290 publications with C6 and Immune System Diseases |
| Inflammation Antibodies | >256 publications with C6 and Inflammation |
| Edema Antibodies | >154 publications with C6 and Edema |
| Congenital Abnormalities Antibodies | >132 publications with C6 and Congenital Abnormalities |
| Kidney Diseases Antibodies | >131 publications with C6 and Kidney Diseases |
Organs/Tissues associated with C6 blocking peptide
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Liver Antibodies | >472 publications with C6 and Liver |
| Kidney Antibodies | >370 publications with C6 and Kidney |
| Heart Antibodies | >299 publications with C6 and Heart |
| Lung Antibodies | >241 publications with C6 and Lung |
| Connective Tissue Antibodies | >85 publications with C6 and Connective Tissue |
| Bladder Antibodies | >72 publications with C6 and Bladder |
| Pancreas Antibodies | >36 publications with C6 and Pancreas |
| Testis Antibodies | >35 publications with C6 and Testis |
| Uterus Antibodies | >15 publications with C6 and Uterus |