1. High expression of LHRH is associated with ovarian cancer.
2. GNRH (and GNRHR) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites.
3. High LHRH expression is associated with sarcomas of bone and soft tissue.
4. mutations in the region encoding the decapeptide associated with complete Idiopathic hypogonadotropic hypogonadism
5. GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/MMP9 expression.
6. analysis of information transfer via gonadotropin-releasing hormone receptors to extracellular signal-regulated kinase or nuclear factor of activated T-cells
7. our results showed that GnRH participates in the self-renewal capacity and stemness maintenance of LCSLCs by upregulating the JNK signaling pathway, and GnRH may be useful as an alternative lung cancer stem-like cells therapy.
8. Melatonin affects the secretion of GnRH, LH and testosterone, improves sperm quality thereby regulating the testicular development and male reproduction. (Review)
9. Data suggest differences in regulation of expression of PEDF (up-regulation) vs. VEGF (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH/GNRHR agonists rather than hCG.
10. No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes
11. Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice.
12. Data indicate that the gene expression pattern is profoundly different between human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist.
13. GnRH agonists fail to increase Bax expression and do not potentiate the cytotoxic activity of docetaxel
14. GnRH, through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 expression levels in some cases of aldosterone-producing adenoma.
15. This review will summarize the current understanding of the mechanisms by which PACAP modulates gonadotrope function, with a focus on interactions with GnRH.
16. Current research efforts aim to discover the mechanisms responsible for the decoding of the GnRH pulse signal by the gonadotrope.
17. GPR101 is a critical requirement for GnRH-(1-5) transactivation of EGFR in Ishikawa cells.
18. This review summarizes the mechanisms used by glial cells to control GnRH neuronal ativity and secretion.
19. R31C GNRH1 is the only missense mutation that was identified in a CpG islet in nine congenital hypogonadotropic hypogonadism subjects from four unrelated families, giving evidence for a putative ''hot spot''.
20. GnRHI, GnRHII and GnRH receptor expression correlated significantly with poor prognosis in breast cancer patients
21. AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival.
22. Olfactory ensheathing cells form a microenvironment for migrating GnRH-1 neurons during development.
23. TRH, LH-RH and substance P are not affected in Alzheimer disease and Down's syndrome
24. Kisspeptin and GnRH pulse generation.
25. Kisspeptin resets the GnRH pulse generator in men, but does not appear to do so in women
26. Spontaneous GnRH release is detected in the median eminence of transgenic mice that produce diurnal variations in GnRH.
27. The role of several class 1 cytokines in regulating GnRH neuronal development, GnRH secretion, and GnRH expression in this REVIEW.
28. data demonstrate that GnRH transcription is repressed by AR via multiple sequences in GnRH-P, including three Oct-1 binding sites, and that this repression requires the complex interaction of several transcription factors
29. molecular mechanisms involved in GnRH/GnRHR signaling at the maternal-fetal interface. [Review]
30. Mutations in GNRH1 have been associated with both mild and severe forms of GnRH deficiency, and may work in combination with other gene mutations to produce GnRH-deficient phenotypes.
31. [review] Existing evidence suggests that neural pathways originating in hindbrain and hypothalamic feeding nuclei transmit information concerning glucose availability to GnRH neurons, which integrate numerous physiological signals and metabolic cues.
32. Data show that higher levels of GnRH IgM antibodies were detected in patients with IBS and dysmotility, but not organic GI diseases, compared with healthy controls.
33. Assessment of CGB and GNRH1 expression level in cancer patients' blood may be useful for indicating metastatic spread of tumor cells.
34. Sleep is associated with a significant decline in GnRH pulse frequency in both older and younger postmenopausal women
35. Deletion of the cell-specific enhancer region of GnRH implicates the GnRH promoter in mediating pubertal development and periodic reproductive cycling.
36. Lactation is an important physiological model of the integration of energy balance and reproduction, as it involves activation of potent appetitive neuropeptide systems coupled to a profound inhibition of pulsatile GnRH/LH secretion--REVIEW
37. A large literature dealing with various stressors that regulate gonadotrophin-releasing hormone secretion in a variety of species provides evidence that stress modulates GnRH secretion by activating the corticotrophin-releasing factor system--REVIEW
38. The sources of glutamatergic inputs to the GnRH neurons are only just beginning to be examined and include the anteroventral periventricular nucleus as well as the possibility that GnRH neurons--REVIEW
39. We then discuss possible neurobiological mechanisms underlying GnRH pulse generation, and conclude by proposing that kisspeptin neurons in the arcuate nucleus are key players--REVIEW
40. homozygous inactivating mutations in the GNRH1 gene causing hypothalamic hypogonadotropic hypogonadism in patients were reported, validating definitively the pivotal role of GnRH in human pubertal development and reproduction--REVIEW
41. GNRH1 mutations might cause congenital idiopathic (or isolated) hypogonadotropic hypogonadism (Review)
42. The role of GnRH-GnRHR signaling at the maternal-fetal interface therefore appears to be limited to the regulation of trophoblast hCG production.
43. Data describe the distribution and sex dimorphism of kisspeptin-immunoreactive elements in hypothalami, reveal contacts between kisspeptin-immunoreactive fibers and GnRH cells, and colocalize kisspeptins and neurokinin B in the infundibular nucleus.
44. Metabolic signals are integrated at the levels of first-order neurons equipped with the proper receptors, ant that these neurons send their signals towards hypothalamic GnRH neurons which constitute the integrative element of this network.
45. The major genes associated with GnRH-dependent pubertal disorders, are reviewed.
46. Review: Using human GnRH deficiency as a paradigm and presenting original data from the screening of numerous candidate genes, we discuss the emerging model of patient-focused clinical genetic research.
47. cadherin switching and p120(ctn) signaling as important targets of GnRH function and as novel mediators of invasiveness and tumor progression in ovarian cancer.
48. data indicate that the promoter region between -992 and -795 contains elements both essential and sufficient for targeting gene expression to GnRH neurons
49. Coupling of GnRH concentration and the GnRH receptor-activated gene program
50. JunD activated by LHRH acts as a modulator of cell proliferation and cooperates with the anti-apoptotic and anti-mitogenic functions of LHRH.

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