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Itacitinib [1334298-90-6]

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Referentie NB-64-27286-5mg

Formaat : 5mg

Merk : Neo Biotech

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Itacitinib

(Synonyms: INCB39110, INCB039110) Copy Product Info

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Synonyms: INCB39110, INCB039110

Catalog No. T3998 Copy Product Info

Purity: 99.5%

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Itacitinib (INCB039110) is an orally bioavailable Janus-associated kinase 1 (JAK1) inhibitor with potential antineoplastic activity.

Cas No. 1334298-90-6

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.5%

Color:White to Yellow

Product Information

Bioactivity

Description	Itacitinib (INCB039110) is an orally bioavailable Janus-associated kinase 1 (JAK1) inhibitor with potential antineoplastic activity.
In vitro	Itacitinib is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1.
In vivo	Itacitinib (INCB039110) produced significant improvements in sPGA, demonstrating proof of concept in chronic plaque psoriasis.
Synonyms	INCB39110, INCB039110

Chemical Properties

Molecular Weight	553.51
Formula	C₂₆H₂₃F₄N₉O
Cas No.	1334298-90-6
Smiles	Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (271 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 10 mg/mL (18.07 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (18.07 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8067 mL	9.0333 mL	18.0665 mL	90.3326 mL
5 mM	0.3613 mL	1.8067 mL	3.6133 mL	18.0665 mL
10 mM	0.1807 mL	0.9033 mL	1.8067 mL	9.0333 mL
20 mM	0.0903 mL	0.4517 mL	0.9033 mL	4.5166 mL
50 mM	0.0361 mL	0.1807 mL	0.3613 mL	1.8067 mL
100 mM	0.0181 mL	0.0903 mL	0.1807 mL	0.9033 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Janus kinaseJAK1JAKItacitinibInhibitorinhibitINCB-39110INCB-039110INCB 39110INCB 039110

Related Tags: Itacitinib chemical structure | Itacitinib in vivo | Itacitinib in vitro | Itacitinib formula | Itacitinib molecular weight