NADPH (tetrasodium salt) [2646-71-1]
Referentie HY-F0003-100mg
Formaat : 100mg
Merk : MedChemExpress
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NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis.
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NADPH tetrasodium salt Chemical Structure
CAS No. : 2646-71-1
This product is a controlled substance and not for sale in your territory.
Based on 7 publication(s) in Google Scholar
Other Forms of NADPH tetrasodium salt:
- NADPH tetracyclohexanamine In-stock
| Description |
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis[1][2][3][4]. |
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| IC50 & Target[1] |
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| In Vitro |
NADPH tetrasodium salt de novo synthesis is catalyzed by NAD kinases (NADKs), which catalyze the phosphorylation of NAD+ to form NADP+. NADPH tetrasodium salt is mainly involved in catabolic reactions, whereas NADPH tetrasodium salt is primarily involved in cellular antioxidative effects and anabolic reactions. NADPH tetrasodium salt is used by glutathione reductase (GR) to reduce oxidized glutathione (GSSG) to GSH[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Masse moléculaire |
833.35 |
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| Formule |
C21H26N7Na4O17P3 |
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| CAS No. |
2646-71-1 |
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| Appearance |
Solid |
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| Color |
Off-white to light yellow |
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| SMILES |
O[C@H]1[C@@H](O)[C@H](N2C=C(C(N)=O)CC=C2)O[C@@H]1COP(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O[Na])(O[Na])=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)(O[Na])=O)(O[Na])=O |
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| Livraison | Room temperature in continental US; may vary elsewhere. |
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| Stockage |
-20°C, stored under nitrogen, away from moisture *The compound is unstable in solutions, freshly prepared is recommended. |
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| Solvant et solubilité |
In Vitro:
H2O : ≥ 35 mg/mL (42.00 mM) DMSO : < 1 mg/mL (insoluble or slightly soluble) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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| Pureté et documentation | |||||||||||||
| Références |
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Complete Stock Solution Preparation Table
* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.2000 mL | 5.9999 mL | 11.9998 mL | 29.9994 mL |
| 5 mM | 0.2400 mL | 1.2000 mL | 2.4000 mL | 5.9999 mL | |
| 10 mM | 0.1200 mL | 0.6000 mL | 1.2000 mL | 2.9999 mL | |
| 15 mM | 0.0800 mL | 0.4000 mL | 0.8000 mL | 2.0000 mL | |
| 20 mM | 0.0600 mL | 0.3000 mL | 0.6000 mL | 1.5000 mL | |
| 25 mM | 0.0480 mL | 0.2400 mL | 0.4800 mL | 1.2000 mL | |
| 30 mM | 0.0400 mL | 0.2000 mL | 0.4000 mL | 1.0000 mL | |
| 40 mM | 0.0300 mL | 0.1500 mL | 0.3000 mL | 0.7500 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.