Human whole blood from geriatric donors is a minimally processed peripheral blood specimen containing erythrocytes, leukocytes, platelets, plasma proteins, metabolites, and soluble mediators. Blood from older individuals provides a complex biological matrix for investigating biological aging, immunosenescence, inflammaging, hematopoiesis, and age-associated molecular changes. Aging is associated with remodeling of circulating immune-cell composition and function, including alterations in T- and B-cell populations, myeloid-cell phenotypes, inflammatory signaling, and immune responses.

Key Features

• Geriatric Human Donor Origin : Supporting age-specific studies and comparisons with younger adult cohorts.

• Whole-Blood Matrix : Retaining circulating cellular and soluble components within an intact ex vivo blood context.

• Broad Research Applications : Suitable for immunophenotyping, flow cytometry, hematological analyses, cytokine profiling, transcriptomic studies, and molecular aging research.

• Aging and Immune Research : Supports investigation of immunosenescence, inflammaging, immune-cell function, and age-associated biomarkers.

Usual Research Uses

• Aging and Gerontology Research : Investigation of age-associated cellular, molecular, and immune changes.

• Immunology and Immunosenescence Studies : Analysis of age-related changes in immune-cell populations, phenotypes, and function.

• Hematology and Immune Profiling : Flow cytometry, immunophenotyping, and hematological analyses of circulating blood cells.

• Biomarker Discovery : Investigation of circulating cellular, protein, cytokine, and molecular biomarkers associated with aging.

• Transcriptomic and Molecular Aging Studies : Analysis of age-associated gene-expression and molecular changes in blood-derived cells.

• Drug-Response Studies : Evaluation of age-dependent cellular and immune responses to experimental treatments.

• Translational Research : Comparative studies of biological aging and age-associated immune alterations in human cohorts.

• Functional Whole-Blood Assays : Ex vivo immune and cellular-response studies, with standardized collection, anticoagulation, storage, and prompt processing to minimize preanalytical effects on cellular phenotype and immune responses.