4-Hydroxynonenal [75899-68-2]
Referentie NB-64-01309-1mg
Formaat : 1mg
Merk : Neo Biotech
4-Hydroxynonenal (Synonyms: 4-HNE)
Catalog No. T10148 Copy Product Info
Purity: 98.88%
4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).
4-Hydroxynonenal
Copy Product InfoSynonyms 4-HNE
4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).
Cas No. 75899-68-2
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). |
| In vitro | 4-Hydroxynonenal (4-HNE) is both a substrate and an inhibitor of ALDH2, with inhibition reversible at low concentrations and becoming irreversible at 10 μM. It induces antioxidant defense mechanisms to limit its own production and enhance cellular protection against oxidative stress. As a product of lipid peroxidation, 4-HNE is mutagenic and genotoxic in viruses, bacteria, and mammalian cells, reacting with all four DNA bases with varying efficiency (G > C > A > T). 4-Hydroxynonenal-dG serves as the best biomarker of its genotoxic effects, primarily found in nuclear DNA [1]. |
| In vivo | Twenty-four hours after fluid percussion injury (FPI), mouse brain tissue is analyzed for the expression levels of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), and 4-Hydroxynonenal (4-HNE). Both wild-type (Nrf2+/+) and Nrf2-deficient (Nrf2-/-) mice show increased 4-HNE expression following a moderate 15 psi injury compared to uninjured controls. In Nrf2-/-knockout mice, 4-HNE expression is significantly higher than in corresponding injured and uninjured Nrf2-/-wild-type animals [2]. |
| Synonyms | 4-HNE |
| Molecular Weight | 156.22 |
| Formula | C9H16O2 |
| Cas No. | 75899-68-2 |
| Smiles | CCCCCC(O)\C=C\C=O |
| Relative Density. | 0.941 g/cm3 |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 249 mg/mL (1593.91 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (32.01 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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