Amcinonide [51022-69-6]
Referentie NB-64-00418-25mg
Formaat : 25mg
Merk : Neo Biotech
Amcinonide (Synonyms: CL-34699)
Catalog No. T0261 Copy Product Info
Purity: 99.74%
Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
Amcinonide
Copy Product InfoSynonyms CL-34699
Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
Cas No. 51022-69-6
Product Introduction
Amcinonide AI Summary
Amcinonide exhibits a diverse range of bioactivities according to various assay data. It shows potent activity in multiple areas, including modulation of miRNAs, activation of miR-21, inhibition of Cruzain, inhibition of neuropeptide S receptor, inhibition of B-Cell Receptor Signaling, inhibition of Histone Lysine Methyltransferase G9a, and inhibition of malarial parasite plastid. Additionally, it inhibits cell surface uPA generation, Lassa and Marburg viruses binding/entry, mutant isocitrate dehydrogenase 1, and Vaccinia Orthopoxvirus, as well as displaying GLP-1 receptor inverse agonism. The compound also induces DNA re-replication in both normal breast and colon cancer cells and synthetic lethality in tumor cells. It exhibits liver-related bioactivity, causing increases in alkaline phosphatase, SGOT, SGPT, LDH, and GGT—key indicators of liver health—though it shows no association with drug-induced liver injuries. Additionally, Amcinonide inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1 transfected CHO cells. Regarding antiviral activity, Amcinonide shows varying results against SARS-CoV-2. It demonstrates potential antiviral activity in Vero E6 cells and HRCE cells; however, the inhibition percentage remains low in certain assays. It posts a bioactivity of 9.76% inhibition of SARS-CoV-2 3CL-Pro protease at a 20µM concentration and inhibits virus-induced cytotoxicity in Vero-6 cells. Nevertheless, it shows no significant inhibition of most targets in the receptor binding assays, suggesting its role as a potential modulator rather than a direct inhibitor across various biological targets..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist. |
| Targets&IC50 | NO release:3.38 nM |
| Synonyms | CL-34699 |
| Molecular Weight | 502.57 |
| Formula | C28H35FO7 |
| Cas No. | 51022-69-6 |
| Smiles | 01[C@@]12C[C@@]3(01)[C@]4(01)CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC1(CCCC1)O2)C(=O)COC(C)=O |
| Relative Density. | 1.33 g/cm3 |
| Storage | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (497.44 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 2.5 mg/mL (4.97 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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