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> Anti-ITGA5 Antibody (3X608)

Anti-ITGA5 Antibody (3X608)

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Referentie NB-64-120338-50uL

Formaat : 50uL

Merk : Neo Biotech


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Anti-ITGA5 Antibody (3X608)

(Synonyms: VLA-5, ITGA5, Integrin α-F, Integrin α-5, Integrin Alpha-F, Integrin Alpha-5, FNRA, Fibronectin Receptor Subunit α, Fibronectin Receptor Subunit Alpha, CD49e, CD49 Antigen-Like Family Member E) Copy Product Info

Synonyms: VLA-5, ITGA5, Integrin α-F, Integrin α-5, Integrin Alpha-F, Integrin Alpha-5, FNRA, Fibronectin Receptor Subunit α, Fibronectin Receptor Subunit Alpha, CD49e, CD49 Antigen-Like Family Member E

Catalog No. TMAH-00643 Copy Product Info
Anti-ITGA5 Antibody (3X608) is an antibody targeting ITGA5. Anti-ITGA5 Antibody (3X608) can be used in ELISA,IHC.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-ITGA5 Antibody (3X608) is an antibody targeting ITGA5. Anti-ITGA5 Antibody (3X608) can be used in ELISA,IHC.
SynonymsVLA-5, ITGA5, Integrin α-F, Integrin α-5, Integrin Alpha-F, Integrin Alpha-5, FNRA, Fibronectin Receptor Subunit α, Fibronectin Receptor Subunit Alpha, CD49e, CD49 Antigen-Like Family Member E
Ig Type
hIgG1
Clone
3X608
Reactivity
Human
Verified Activity
IHC image of TMAH-00643 diluted at 1:50 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
Application
ELISA
IHC
Recommended Dose
IHC:1:50-1:200.
Antibody Type
Monoclonal
Subcellular LocalizationMembrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface.
ConstructionRecombinant Antibody
PurificationAffinity-chromatography
AppearanceLiquid
FormulationPreservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
Research BackgroundIntegrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human ITGA5 Protein
Antigen Species
Human
Gene Name
ITGA5
Gene ID
3678
Uniprot ID
P08648
Biology Area
Signal transduction, Stem cells
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Keywords

VLA5VLA 5ITGA-5ITGA 5Integrin a-FIntegrin a-5
Related Tags: Anti-ITGA5 Antibody (3X608) chemical structure