Anti-Wnt11 Polyclonal Antibody 2
Referentie NB-64-164102-100uL
Formaat : 100uL
Merk : Neo Biotech
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Anti-Wnt11 Polyclonal Antibody 2
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Catalog No. TMAB-14185 Copy Product Info
Anti-Wnt11 Polyclonal Antibody 2 is a Rabbit antibody targeting Wnt11. Anti-Wnt11 Polyclonal Antibody 2 can be used in WB.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Wnt11 Polyclonal Antibody 2 is a Rabbit antibody targeting Wnt11. Anti-Wnt11 Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse,Human (predicted:Rat) |
| Verified Activity | 1. 20 ng rmWnt11-Trx-His protein per lane probed with Wnt11 polyclonal antibody respectively, unconjugated (TMAB-14185) at 1:1000 dilution and 4°C overnight incubation. Followed by corresponding conjugated secondary antibody incubation at r. T. for 60 min. 2. 25 μg total protein per lane of various lysates (see on figure) probed with Wnt11 polyclonal antibody, unconjugated (TMAB-14185) at 1:500 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | WB |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted; extracellular space; extracellular matrix. |
| Tissue Specificity | Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The Wnt genes belong to a family of protooncogenes with at least 13 known members that are expressed in species ranging from Drosophila to man. The name Wnt denotes the relationship of this family to the Drosophila segment polarity gene ”wingless” and to its vertebrate ortholog, Int-1, a mouse proto-oncogene. Transcription of Wnt family genes appears to be developmentally regulated in a precise temporal and spatial manner. The Wnt genes encode cysteine-rich putative glycoproteins which have features typical of secreted growth factors. Wnt-11 is expressed in the tips of ureteric buds and in the perichondrium, a stem cell-like layer that surrounds the future bones and directs their growth and regeneration. Wnt-11 activity is required for cells to undergo correct convergent extension movements during gastrulation. Human Wnt-11 is also expressed in the lung mesenchyme, the urorectal septum, the urogenital folds, the labioscrotal swellings, and the cortex of the adrenal gland. Unlike other Wnt family members, Wnt-11 is not expressed in the neuroepithelium of the central nervous system. Wnt-11, along with Wnt-8c, is ex-pressed in the posterior region of the chick embryo in the caudal paraxial mesoderm that underlies the prospective caudal neural plate. The gene which encodes Wnt-11 maps to human chromosome 11q13.5. |
| Immunogen | Recombinant Protein: mouse Wnt11 protein |
| Antigen Species | Mouse |
| Gene Name | WNT11 |
| Gene ID | 22411 |
| Protein Name | Protein Wnt-11 |
| Uniprot ID | P48615 |
| Function | Wnt11 is a non-canonical Wnt which is expressed in androgen-independent prostate cancer cell lines and prostate tumours. It is involved in development, including cardiac and gut development. |
| Molecular Weight | Theoretical: 39 kDa. Actual: 50 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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