Astragalus membranaceus Lectin (AML)
Referentie L1367-10
Formaat : 10mg
Merk : GLYcoDiag
Astragalus membranaceus lectin (AML)
| Reference | Short Name | Common Name | Inhibitory Carbohydrate | Glycans Structures Specifities |
|---|---|---|---|---|
| L1367 | AML | Astragalus membranaceus | Gal | Galβ |
Astragalus membranaceus (AML), a chinese herb, is isolated from dried roots by successive ammonium sulphate fractionation (1). AML is a monomeric lectin with a molecular weight of 31,5 kDa.
AML is a galactose-binding lectin, which is best inhibited by D-galactose and its derivatives, with pronounced preference for o-nitrophenyl-b-D-galactopyranoside (2).
AML have high thermostability and pH stability. In fact, AML keep it full hemagglutinating properties up to 55 °C for 30 min and in broad range pH from 5,5 to 12,0 (2).
Applications
Validated in GLYcoPROFILE®
Hemagglutinating activity
Anti-proliferative activity and apoptosis induction of various
type of cancer cells
Features
β-Gal binding lectin
Ordering informations
| Reference | Name | Quantity |
|---|---|---|
| L1367-10 | AML lectin | 10 mg |
| L1367-2 | AML lectin | 2 mg |
References
(1) Yan, Q., Zhu, L., Kumar, N., Jiang, Z., Huang, L., Characterisation of a novel monomeric lectin (AML) from Astragalus membranaceus with anti-proliferative activty. 2010, 122, 589-595.
(2) Huang, L.H., Yan, Q. J., Kopparapu, N. K., Jiang, Z. Q., Sun, Y., Astragalus membranaceus lectin (AML) induces caspase-dependent apoptosis in human leukemia cells, 2012, 45, 15-21.
| Reference | Short Name | Common Name | Inhibitory Carbohydrate | Glycans Structures Specifities | |
|---|---|---|---|---|---|
| L1222 | ABA | Agaricus Bisporus | Gal/GalNAc | Gal(β-1,3) GaINAc | |
| L1221 | AIA / Jacalin | Artocarpus intergrifolia | Gal | Galα1-6 or Galβ1-3GalNAc (T-antigen)>> lactose, more specific for T-antigen than PNA | |
| L1367 | AML | Astragalus membranaceus | Gal | Galβ | |
| L1205 | ASA | Allium sativum agglutinin | α(1,3)Man | Mannose | |
| L1889 | BanLec | Musa acuminata | Mannose, Glucose | αMan | |
| L1255 | BC2L-A | Burkholderia cenocepacia | α(1,3)Man | Mannose-containing ligands | |
| L1256 | BC2L-C | Burkholderia cenocepacia | Lewis b / Lewis Y | Fucose containing ligands | |
| L1254 | CJA | Crotalaria juncea | lactose | Gal > GalNAc | |
| L1366 | cMol | Moringa oleifera | fetuin, thyroglobuline | GlcNAc, Complex carbohydrate-binding specificity | |
| L1201 | Con A | Concanavalin A | MeαMan | α-Man, Glc | See more details
|