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> Aucubin [479-98-1]

Aucubin [479-98-1]

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Referentie NB-64-22034-5mg

Formaat : 5mg

Merk : Neo Biotech


Aucubin (Synonyms: Rhinanthin, Aucuboside)

Catalog No. T3416 Copy Product Info
Purity: 99.83%
Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.

Aucubin

Copy Product Info
Synonyms Rhinanthin, Aucuboside

Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.

Aucubin
Cas No. 479-98-1
Other Forms of Aucubin:
Aucubin (Standard)TMSM-2842479-98-1
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Batch Information
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Purity:99.83%
Color:White to Red
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Product Introduction
Aucubin AI Summary
Aucubin exhibits a range of bioactivities, including inhibiting the classical complement pathway activation at 4 µM with significantly higher inhibition (89.3%) in the presence of beta glucosidase. It demonstrates potent inhibition of L3MBTL1 (63.1 nM) and induces DNA re-replication (183.6 nM) in SW480 colon adenocarcinoma cells. The compound also shows estrogenic activity at the ERalpha in human MVLN cells with activities of 81.25% and 99.1% at concentrations of 100 µg/mL and 20 µg/mL, respectively, compared to E2. It inhibits electric eel Acetylcholinesterase (AChE) and horse Butyrylcholinesterase (BChE) at 2 mg/mL, although the inhibition percentages are modest (-1.28% for AChE and -12.67% for BChE). Additionally, it exhibits moderate to high inhibitory activity against the COX1 enzyme (48.2% to 50.2%) but weaker activity against the COX2 enzyme (below 30%). It shows no significant cytotoxicity against various human cancer cell lines (IC50 > 10000 nM) and demonstrates minimal inhibitory effects against SARS-CoV-2 3CL-Pro protease (0.17% at 20 µM). Lastly, it exhibits 0.14% inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
SynonymsRhinanthin, Aucuboside
Chemical Properties
Molecular Weight346.33
FormulaC15H22O9
Cas No.479-98-1
SmilesOCC1OC(OC2OC=CC3C(O)C=C(CO)C23)C(O)C(O)C1O
Relative Density.1.61 g/cm3
Storage & Solubility Information
StorageShipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 0.12 mg/mL (0.35 mM), Sonication is recommended
H2O: Insoluble
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.77 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.