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Bikinin [188011-69-0]

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Referentie NB-64-09490-1mL

Formaat : 1mLx10mM(inDMSO)

Merk : Neo Biotech

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Bikinin

(Synonyms: Abrasin) Copy Product Info

Synonyms: Abrasin

Catalog No. T1965 Copy Product Info

Purity: >99.99%

Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.

Cas No. 188011-69-0

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.86%

Appearance:Solid

Color:White

Product Information

Bikinin AI Summary

Bikinin exhibits diverse bioactivities: it acts as an agonist for the Thyroid Stimulating Hormone Receptor (potency: 5011.9 nM), an activator of intracellular cAMP concentrations in HEK 293 cells, an inhibitor of AmpC Beta-Lactamase (potency: 3981.1 nM), an inhibitor of ROR gamma transcriptional activity (potency: 562.3 nM), a re-activator of p53 (potency: 19952.6 nM), an inhibitor of HP1-beta Chromodomain interactions with methylated histone tails (potency: 79432.8 nM), and an agonist of gsp, the etiologic mutation responsible for Fibrous Dysplasia/McCune-Albright Syndrome (potency: 1258.9 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.
In vitro	Bikinin directly inhibited BIN2 in Arabidopsis GSK-3s and activated oleuropein steroid-dependent gene expression.Bikinin also inhibited RD26 expression and, in the case of RD26pro:GUS, NaCl (150 mM)-induced GUS activity.
In vivo	Bikinin directly inhibited BIN2 in Arabidopsis GSK-3s and activated oleuropein steroid-dependent gene expression.Bikinin also inhibited RD26 expression and, in the case of RD26pro:GUS, NaCl (150 mM)-induced GUS activity.
Synonyms	Abrasin

Chemical Properties

Molecular Weight	273.083
Formula	C₉H₉BrN₂O₃
Cas No.	188011-69-0
Smiles	OC(=O)CCC(=O)NC1=NC=C(Br)C=C1
Relative Density.	1.711 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 100.00 mg/mL (366.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10.00 mg/mL (36.62 mM), Solution.

10% DMSO+90% Saline: < 10 mg/mL (36.62 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6619 mL	18.3095 mL	36.6189 mL	183.0945 mL
5 mM	0.7324 mL	3.6619 mL	7.3238 mL	36.6189 mL
10 mM	0.3662 mL	1.8309 mL	3.6619 mL	18.3095 mL
20 mM	0.1831 mL	0.9155 mL	1.8309 mL	9.1547 mL
50 mM	0.0732 mL	0.3662 mL	0.7324 mL	3.6619 mL
100 mM	0.0366 mL	0.1831 mL	0.3662 mL	1.8309 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Shaggy-like kinaseInhibitorinhibitGSK-3GSK3Glycogen synthase kinase-3Glycogen synthase kinase 3Bikinin

Related Tags: Bikinin chemical structure | Bikinin in vivo | Bikinin in vitro | Bikinin formula | Bikinin molecular weight