Cephalosporin C zinc salt [59143-60-1]

Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC₅₀ of 1.1 μM^[1]. Cephalosporin C zinc salt also has moderate anti-orthopoxvirus activity^[2].

Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC₅₀ of 1.1 ± 0.1 μM, 200-fold more potent than Na⁺ salt form of Cephalosporin C (ICC₅₀^CC-Na = 213 ± 30 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Seamon KJ, et al. A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen. 2015 Jul;20(6):801-9.  [Content Brief]

  [2]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.  [Content Brief]