Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.
 
> CytoSelect™ 24-Well Cell Contraction Assay Kit (Floating Matrix Model)

CytoSelect™ 24-Well Cell Contraction Assay Kit (Floating Matrix Model)

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Referentie CBA-5020

Formaat : 24assays

Merk : Cell Biolabs


Cell Contraction Assays, Floating Matrix Model
  • Proprietary contraction plate eliminates release step
  • Uses 3D collagen matrix to measure changes in collagen gel size
  • Includes optional cell contraction inhibitor
CytoSelect™ 24-Well Cell Contraction Assay Kit (Floating Matrix Model)
Catalog Number
CBA-5020
Size
24 assays
Detection
Light Microscopy
Manual/Data Sheet Download
SDS Download
CytoSelect™ 48-Well Cell Contraction Assay Kit
Catalog Number
CBA-5021
Size
48 assays
Detection
Light Microscopy
Manual/Data Sheet Download
SDS Download
Product Details

In the floating matrix contraction model, a freshly polymerized collagen matrix containing cells is released from the culture dish and allowed to float in culture medium, and contraction occurs in the absence of external mechanical load and without appearance of stress fibers in the cells.

Cell Biolabs’ Cell Contraction Assays (Floating Matrix Model) provide a simple, in vitro system to assess cell contractility and screen cell contraction mediators.  The proprietary Cell Contraction Plate eliminates the matrix releasing step of the conventional contraction assay, providing a faster, higher-throughput method to assess cell contraction.

Recent Product Citations
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  2. Okamoto, R. et al. (2026). Transgelin Expression in Activated Cancer-Associated Fibroblasts Regulates Stromal Contractility and Promotes Colon Cancer Progression. Cancer Med. 15(4):e71789. doi: 10.1002/cam4.71789 (#CBA-5020).
  3. Chen, X. et al. (2026). Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging via H3K4me3-dependent SASP suppression. Acta Pharm Sin B. doi: 10.1016/j.apsb.2026.02.006 (#CBA-5020).
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  5. Romano, E. et al. (2025). Soluble α-Klotho protects dermal microvascular endothelial cells against endothelial-to-mesenchymal transition. Tissue Cell. doi: 10.1016/j.tice.2025.103029 (#CBA-5020).
  6. Ding, Q. et al. (2025). Genomic Editing of a Pathogenic Mutation in ACTA2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice. Circulation. doi: 10.1161/CIRCULATIONAHA.125.074218 (#CBA-5020).
  7. Li, W.Z. et al. (2024). Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin. World J Gastroenterol. 30(45):4817-4835. doi: 10.3748/wjg.v30.i45.4817 (#CBA-5020).
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  9. Liu, Y. et al. (2024). Isoform-independent promotion of contractility and proliferation, and suppression of survival by with no lysine/K kinases in prostate stromal cells. FASEB J. 38(7):e23604. doi: 10.1096/fj.202400362R (#CBA-5020).
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  12. Debele, T.A. et al. (2023). The Effects of ROCK Inhibitor on Prevention of Dexamethasone-Induced Glaucoma Phenotype in Human Trabecular Meshwork Cells. Transl Vis Sci Technol. 12(12):4. doi: 10.1167/tvst.12.12.4 (#CBA-5020).
  13. Romano, E. et al. (2022). Soluble guanylate cyclase stimulation fosters angiogenesis and blunts myofibroblast-like features of systemic sclerosis endothelial cells. Rheumatology (Oxford). doi: 10.1093/rheumatology/keac433 (#CBA-5020).
  14. Saputra, E. et al. (2025). In vitro models of cancer-associated fibroblast heterogeneity uncover subtype-specific effects of CRISPR perturbations. Mol Oncol. doi: 10.1002/1878-0261.70153 (#CBA-5021).
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  19. Park, S.Y. et al. (2021). Nano-Graphene Oxide-Promoted Epithelial–Mesenchymal Transition of Human Retinal Pigment Epithelial Cells through Regulation of Phospholipase D Signaling. Nanomaterials. 11(10):2546. doi: 10.3390/nano11102546 (#CBA-5021).
  20. Peavey, M.C. et al. (2021). Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility. Proc Natl Acad Sci U S A. 118(11):e2011643118. doi: 10.1073/pnas.2011643118 (#CBA-5021).
  21. Ahn, S.H. et al. (2021). MicroRNA-139-5p Regulates Fibrotic Potentials via Modulation of Collagen Type 1 and Phosphorylated p38 MAPK in Uterine Leiomyoma. Yonsei Med J. 62(8):726-733. doi: 10.3349/ymj.2021.62.8.726 (#CBA-5020).
  22. Moreno, S.E. et al. (2021). Dehydrated Human Amniotic Membrane Inhibits Myofibroblast Contraction through Regulation of the TGF-β1/SMAD Pathway In Vitro. JID Innov. doi: 10.1016/j.xjidi.2021.100020 (#CBA-5020).
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  24. Pachera, E. et al. (2020). Long noncoding RNA H19X is a key mediator of TGFβ driven fibrosis. J Clin Invest. doi: 10.1172/JCI135439 (#CBA-5021).
  25. Knitlova, J. et al. (2020). Minoxidil decreases collagen I deposition and tissue-like contraction in clubfoot-derived cells: a way to improve conservative treatment of relapsed clubfoot? Connect Tissue Res. doi: 10.1080/03008207.2020.1816992 (#CBA-5020).
  26. Chen, G. et al. (2020). β-Adrenoceptor regulates contraction and inflammatory cytokine expression of human bladder smooth muscle cells via autophagy under pathological hydrostatic pressure. Neurourol Urodyn. doi: 10.1002/nau.24517 (#CBA-5020).
  27. Shimizu, H. et al. (2020). Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 61(11):21. doi: 10.1167/iovs.61.11.21 (#CBA-5021).
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