glycine [56-40-6]
Referentie T2O2728-500mg
Formaat : 500mg
Merk : TargetMol
glycine
(Synonyms: Glycosthene, Glycolixir, Glycocoll, Aminoacetic acid, 2-Aminoacetic acid) Copy Product Info
glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
Cas No. 56-40-6
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.39%
Appearance:Solid
Color:White
COA HPLC LCMS HNMR
Product Information
glycine AI Summary
glycine shows significant bioactivity across multiple domains. It demonstrates binding affinity for the glycine binding site of the NMDA receptor, with reported IC50 values ranging from 86.0 nM to 690.0 nM and a Ki value of 125.89 nM. It inhibits the binding of [3H]5,7-dichlorokynurenic acid and [3H]MK 801 to NMDA receptors, with various EC50 values highlighting its potency across different receptor subunits (NR2A, NR2B, NR2C, and NR2D). glycine exhibits activity in inhibiting the [3H]strychnine binding to glycine receptors (IC50 of 6000.0 nM), GABA transporters (with IC50 values between 1.35µM and 3.1µM), and human LAT1 transporters. It also shows cytotoxicity against drug-resistant KBV1 cells at very high concentrations (>50,000,000.0 nM). Further, glycine demonstrates anticonvulsant and antiepileptic activities by reducing seizure incidence in various tests, such as the MES and strychnine tests, and it also exhibits analgesic effects in mice. The compound has potential antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity and Ebola viral entry. Biochemical assays reveal it as a potential HDAC6 inhibitor and an antagonist at human glycine alpha-1 receptor with EC50 values around 94,000.0 nM. The physico-chemical properties include a pKa value of 9.8, a logP value of 3.21, and significant human intestinal absorption at 1.0%. Lastly, glycine exhibits a broad spectrum of interactions with various transporters and enzymes, indicating its diverse potential as a pharmacological agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. |
| Targets & IC50 | MT2 receptor:9.8(pKi), MT1 receptor:9.45(pKi) |
| Synonyms | Glycosthene, Glycolixir, Glycocoll, Aminoacetic acid, 2-Aminoacetic acid |
| Molecular Weight | 75.07 |
| Formula | C2H5NO2 |
| Cas No. | 56-40-6 |
| Smiles | O=C(O)CN |
| Relative Density. | 1.595 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 100 mg/mL (1332.09 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||