HRP-Linked Polyclonal Antibody to Neurotrophin 4 (NT4)

This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]

NT-4/5: Target-derived survival factor for peripheral sensory sympathetic neurons. Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O). A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Belongs to the NGF-beta family.

Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: endoplasmic reticulum lumen; extracellular region

Molecular Function: neurotrophin p75 receptor binding; protein binding

Biological Process: adult locomotory behavior; cell-cell signaling; epidermis development; ganglion mother cell fate determination; long-term memory; negative regulation of neuron apoptosis; neurite morphogenesis; regulation of neuron differentiation; sensory organ boundary specification; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Glaucoma 1, Open Angle, O