OASB02785 | Human Lambda Antibody : PE Clinisciences

Goat Anti-Human Lambda Antibody - PE Conjugated (OASB02785)

Datasheets/Manuals	Printable datasheet for Goat Anti-Human Lambda Antibody - PE Conjugated (OASB02785)

Product Info
Tested Species Reactivity	Human
Predicted Species Reactivity	Human
Product Format	Liquid. Phosphate buffered saline containing 0.1% sodium azide and a stabilizer
Clonality	Polyclonal
Host	Goat
Conjugation	R-PE
Application	FC, FLISA
Additional Information	Description: Pooled antisera from goats hyperimmunized with human lambda light chains; purified by affinity chromatography on human lambda light chains covalently linked to agarose; reacts with human lambda light chains; cross-adsorbed against human kappa light chains / mouse immunoglobulins and pooled sera for minimal reactivity
Reconstitution and Storage	Store at 2-8C
Immunogen	Human lambda light chains
Concentration	0.5 mg/mL
Specificity	Lambda

Gene Symbol	IGL
Gene Full Name	immunoglobulin lambda locus
Alias Symbols	IGL@, IGLC6
NCBI Gene Id	3535
Protein Name	ig lambda-6 chain C region
Description of Target	Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species.