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> MALTOTETRAOSE [34612-38-9]

MALTOTETRAOSE [34612-38-9]

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Referentie orb1301492-10mg

Formaat : 10mg

Merk : Biorbyt


MALTOTETRAOSE

SKU: orb1301492

Description

Maltotetraose (Fujioligo 450) is a potent suppressor of TNF-α-induced ICAM-1 expression. This activity suggests its potential application in researching early atherosclerotic events, supported by in vitro studies on endothelial cell inflammation.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Images & Validation

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MALTOTETRAOSE

Key Properties

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CAS Number34612-38-9
MW666.58
Purity99.02% (May vary between batches)
FormulaC24H42O21
SMILESOC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]4CO)O[C@@H]3CO)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O
TargetEndogenous Metabolite|||TNF
SolubilityDMSO:55 mg/mL (82.51 mM)

Bioactivity

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In Vivo
Maltotetraose reduced PDGF-induced sprout formation by mouse aorta explants and inhibited TNF-α-induced NF-κB activation and ICAM-1 expression in MOVAS-1 cells.
Animal Research
Ex vivo migration of VSMCs was measured by aortic . Mouse thoracic aortas were excised from 8-week-old male Balb/c mice and adipose tissue was removed. The aortas were sectioned into 1-mm–long cross-sections, rinsed with serum-free DMEM, treated with 1 mg/mL collagenenase type II, placed in matrigel-coated wells, covered with 50 uL matrigel, and allowed to gel for more than 30 min at 37℃ in a 5% CO2 atmosphere. The aortic rings were treated with 20 ug/mL MALTOTETRAOSE for 30 min, followed by stimulation with 20 ng/mL PDGF-BB. Aortic ring sprouts were photographed on day 7.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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alpha-1,4-Tetraglucose, Amylotetraose, a-1,4-Tetraglucose, MALTOTETRAOSE, Endogenous Metabolite, EndogenousMetabolite, Fujioligo 450, Fujioligo450, Fujioligo-450, inhibit, Inhibitor, TNF-α, α-1,4-Tetraglucose
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Compound Identifiers

PubChem CID
446495 ↗

Key Properties

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No computed properties available.

Protocol Information