Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.

Mitomycin C [50-07-7]

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Referentie NB-64-110297-1mg

Formaat : 1mg

Merk : Neo Biotech

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Mitomycin C

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Synonyms:

Catalog No. T6890 Copy Product Info

Purity: 99.76%

Mitomycin C (Ametycine) is an antineoplastic agent and DNA double-strand crosslinking agent capable of inducing DNA damage, inhibiting DNA synthesis, suppressing mitosis, and activating apoptosis. Mitomycin C is a broad-spectrum antibiotic against both Gram-negative and Gram-positive bacteria.

Cas No. 50-07-7

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.76%

Appearance:Solid

Color:Black

Product Introduction

Bioactivity

Description	Mitomycin C (Ametycine) is an antineoplastic agent and DNA double-strand crosslinking agent capable of inducing DNA damage, inhibiting DNA synthesis, suppressing mitosis, and activating apoptosis. Mitomycin C is a broad-spectrum antibiotic against both Gram-negative and Gram-positive bacteria.

Chemical Properties

Molecular Weight	334.37
Formula	C₁₅H₁₈N₄O₅
Cas No.	50-07-7
Smiles	CO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41.66 mg/mL (124.59 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9907 mL	14.9535 mL	29.9070 mL	149.5349 mL
5 mM	0.5981 mL	2.9907 mL	5.9814 mL	29.9070 mL
10 mM	0.2991 mL	1.4953 mL	2.9907 mL	14.9535 mL
20 mM	0.1495 mL	0.7477 mL	1.4953 mL	7.4767 mL
50 mM	0.0598 mL	0.2991 mL	0.5981 mL	2.9907 mL
100 mM	0.0299 mL	0.1495 mL	0.2991 mL	1.4953 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

MitomycinCDNAAlkylatorDNA/RNA SynthesisDNA synthesisDNA Alkylator/CrosslinkerDNA AlkylatorCrosslinkerBacterialApoptosisAntibioticADC Cytotoxin

Related Tags: Mitomycin C chemical structure | Mitomycin C formula | Mitomycin C molecular weight