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Overview
Novel diacylglycerol (DAG) photoswitch, enabling efficient control of TRPC3 by light
Chemical Properties
| Molecular Formula | C43H52N4O5 |
| Molecular Weight | 704.39 |
| CAS Numbers | 2230617-93-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 3-hydroxypropane-1,2-diyl bis(4-(4-((E)-(4-butylphenyl)diazenyl)phenyl)butanoate) |
| InChl Key | ZBBHLPDZJFKXFD-NFAUJPPVSA-N |
| InChl Code | InChI=1S/C43H52N4O5/c1-3-5-9-33-15-23-37(24-16-33)44-46-39-27-19-35(20-28-39)11-7-13-42(49)51-32-41(31-48)52-43(50)14-8-12-36-21-29-40(30-22-36)47-45-38-25-17-34(18-26-38)10-6-4-2/h15-30,41,48H,3-14,31-32H2,1-2H3/b46-44+,47-45+ |
| SMILES Code | CCCCC1=CC=C(/N=N/C2=CC=C(CCCC(OCC(CO)OC(CCCC3=CC=C(/N=N/C4=CC=C(CCCC)C=C4)C=C3)=O)=O)C=C2)C=C1 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
OptoDArG; Opto-DArG; Opto DArG
References
Lichtenegger M, Tiapko O, Svobodova B, Stockner T, Glasnov TN, Schreibmayer W, Platzer D, de la Cruz GG, Krenn S, Schober R, Shrestha N, Schindl R, Romanin C, Groschner K. An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Nat Chem Biol. 2018 Apr;14(4):396-404. doi: 10.1038/s41589-018-0015-6. Epub 2018 Mar 19. PubMed PMID: 29556099; PubMed Central PMCID: PMC5903546.

