Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses. [[654671-78-0]]
Referentie orb1910069-100mg
Formaat : 100mg
Merk : Biorbyt
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Sitagliptin phosphate
Catalog Number: orb1910069
| Catalog Number | orb1910069 |
|---|---|
| Category | Small Molecules |
| Description | Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses. |
| CAS Number | [654671-78-0] |
| MW | 505.3088 |
| SMILES | P(=O)(O02)(O02)O02.FC(C1=NN=C2C(02)(02)N(C(C(02)(02)[C@@](02)(C(02)(02)C3=C(02)C(=C(C(02)=C3F)F)F)N(02)02)=O)C(02)(02)C(02)(02)N21)(F)F |
| Formula | C16H18F6N5O5P |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |