TRB-3 (Tribbles Homolog 3, Neuronal Cell death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappaB)
Referentie MBS6001176-5x0,1mg
Formaat : 5x0.1mg
Merk : MyBiosource
Immunohistochemical staining of of human tissue using MBS6001176 at 1:2000 dilution. 1: Immunoperoxidase staining (cytoplasmic) of formalin-fixed, paraffin-embedded human salivary glands (200x, brown color).
Western blot analysis of human tissue lysate using MBS6001176 at 1:2000 dilution. 1. Human spleen tissue lysate (10ug). 2. Human liver tissue lysate (10ug) 3. Human colon tissue lysate (10ug) 4. Human Thpok (His-tagged) (negative control).
TRIB3 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6001176Tribbles homolog 3 (TRB-3) is a pseudokinase, shown to act as a potent negative regulator of PPAR?, a master regulator of adipocyte differentiation, and to control adipogenesis. It disrupts insulin signaling by binding directly to Akt kinases and blocking… More details
Product Overview
Online Datasheet in PDFProduct Name
TRB-3 (TRIB3), Polyclonal Antibody
Full Product Name
TRB-3 (Tribbles Homolog 3, Neuronal Cell death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappaB)
Product Gene Name
anti-TRIB3 antibody
Product Synonym Names
Anti -TRB-3 (Tribbles Homolog 3, Neuronal Cell death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappaB)
Clonality
Polyclonal
Host
Rabbit
Form/Format
Supplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Specificity
Recognizes human TRB-3. Detects a band of ~28kD by Western blot (predicted 39kD).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
39,578 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (356447..378203). Location: 20p13-p12.2
OMIM
607898
Immunogen
Synthetic peptide corresponding to aa 112-125 (A112RLPPHKHVARPTE125) of human TRB-3.
Product Categories/Family for anti-TRIB3 antibody
Antibodies; Abs to Protein Kinase Inhibitors
Applications Tested/Suitable for anti-TRIB3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TRIB3 antibody
Suitable for use in ELISA, Immunohistochemistry, Western Blot
Other Notes
Small volumes of anti-TRIB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for TRIB3 purchase
MBS6001176 is an antibody targeting TRIB3. Also known as TRB-3 (Tribbles Homolog 3, Neuronal Cell death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappaB). Host: Rabbit.
Additional Details
NCBI/Uniprot data below describe general gene information for TRIB3. It may not necessarily be applicable to this product.
NCBI Official Full Name
tribbles homolog 3
NCBI Official Synonym Full Names
tribbles homolog 3 (Drosophila)
NCBI Official Symbol
TRIB3
NCBI Official Synonym Symbols
NIPK; SINK; TRB3; SKIP3; C20orf97
UniProt Protein Name
Tribbles homolog 3
UniProt Synonym Protein Names
Neuronal cell death-inducible putative kinase; SINK; p65-interacting inhibitor of NF-kappa-B
Protein Family
Tribbles
UniProt Gene Name
TRIB3
UniProt Synonym Gene Names
C20orf97; NIPK; SKIP3; TRB3; TRB-3
UniProt Entry Name
TRIB3_HUMAN
NCBI Protein Information
tribbles homolog 3; TRB-3; p65-interacting inhibitor of NF-kappaB; p65-interacting inhibitor of NF-kappa-B; neuronal cell death inducible putative kinase; neuronal cell death-inducible putative kinase
NCBI Summary for TRIB3
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for TRIB3
TRB3: a Ca(2)/calmodulin-dependent protein kinase of the Trbl family. Induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. May negatively regulate the cell survival kinase AKT1.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; Trbl family
Chromosomal Location of Human Ortholog: 20p13-p12.2
Cellular Component: nucleoplasm; plasma membrane; cytosol; nucleus
Molecular Function: protein binding; protein kinase inhibitor activity; ubiquitin-protein ligase regulator activity; ubiquitin protein ligase binding; kinase activity; transcription corepressor activity; protein kinase binding; ATP binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of protein binding; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; protein amino acid phosphorylation; cellular response to insulin stimulus; regulation of MAP kinase activity; positive regulation of ubiquitin-protein ligase activity; insulin receptor signaling pathway; innate immune response; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; negative regulation of fatty acid biosynthetic process
Show more Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; Trbl family
Chromosomal Location of Human Ortholog: 20p13-p12.2
Cellular Component: nucleoplasm; plasma membrane; cytosol; nucleus
Molecular Function: protein binding; protein kinase inhibitor activity; ubiquitin-protein ligase regulator activity; ubiquitin protein ligase binding; kinase activity; transcription corepressor activity; protein kinase binding; ATP binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of protein binding; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; protein amino acid phosphorylation; cellular response to insulin stimulus; regulation of MAP kinase activity; positive regulation of ubiquitin-protein ligase activity; insulin receptor signaling pathway; innate immune response; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; negative regulation of fatty acid biosynthetic process
Research Articles on TRIB3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-TRIB3 antibody
| Reference Product | PubMed Publications |
|---|---|
| ATF4 antibody | >25 publications with TRIB3 and ATF4 |
| AKT1 antibody | >4 publications with TRIB3 and AKT1 |
| AKT2 antibody | >2 publications with TRIB3 and AKT2 |
Pathways associated with anti-TRIB3 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Activation Of PKB Pathway antibodies | Activation Of PKB Pathway Diagram |
| Adaptive Immune System Pathway antibodies | Adaptive Immune System Pathway Diagram |
| Adipogenesis Pathway antibodies | Adipogenesis Pathway Diagram |
| CD28 Co-stimulation Pathway antibodies | CD28 Co-stimulation Pathway Diagram |
| CD28 Dependent PI3K/Akt Signaling Pathway antibodies | CD28 Dependent PI3K/Akt Signaling Pathway Diagram |
| Costimulation By The CD28 Family Pathway antibodies | Costimulation By The CD28 Family Pathway Diagram |
| DAP12 Interactions Pathway antibodies | DAP12 Interactions Pathway Diagram |
| DAP12 Signaling Pathway antibodies | DAP12 Signaling Pathway Diagram |
| Disease Pathway antibodies | Disease Pathway Diagram |
| Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies | Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram |
Diseases associated with anti-TRIB3 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Insulin Resistance Antibodies | >34 publications with TRIB3 and Insulin Resistance |
| Neoplasms Antibodies | >32 publications with TRIB3 and Neoplasms |
| Cardiovascular Diseases Antibodies | >17 publications with TRIB3 and Cardiovascular Diseases |
| Inflammation Antibodies | >9 publications with TRIB3 and Inflammation |
| Necrosis Antibodies | >7 publications with TRIB3 and Necrosis |
| Liver Diseases Antibodies | >7 publications with TRIB3 and Liver Diseases |
| Carcinoma, Hepatocellular Antibodies | >6 publications with TRIB3 and Carcinoma, Hepatocellular |
| Breast Neoplasms Antibodies | >6 publications with TRIB3 and Breast Neoplasms |
| Heart Diseases Antibodies | >5 publications with TRIB3 and Heart Diseases |
| Liver Neoplasms Antibodies | >4 publications with TRIB3 and Liver Neoplasms |
Organs/Tissues associated with anti-TRIB3 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >23 publications with TRIB3 and Blood |
| Muscle Antibodies | >22 publications with TRIB3 and Muscle |
| Liver Antibodies | >20 publications with TRIB3 and Liver |
| Vascular Antibodies | >8 publications with TRIB3 and Vascular |
| Bone Antibodies | >8 publications with TRIB3 and Bone |
| Pancreas Antibodies | >7 publications with TRIB3 and Pancreas |
| Kidney Antibodies | >5 publications with TRIB3 and Kidney |
| Bone Marrow Antibodies | >5 publications with TRIB3 and Bone Marrow |
| Connective Tissue Antibodies | >3 publications with TRIB3 and Connective Tissue |
| Lung Antibodies | >3 publications with TRIB3 and Lung |