- Specifications
Product Description
Made to order FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. ().
Origin
Human
Source
Genomic DNA
Reactivity
Human
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Supplied Products
DAPI Counterstain (1500 ng/mL ) 250 uL
Storage Instruction
Store at 4°C in the dark.
- Applications
Fluorescent In Situ Hybridization (Cell)
- Gene Info — WT1
Entrez GeneID
7490Gene Name
WT1
Gene Alias
GUD, WAGR, WIT-2, WT33
Gene Description
Wilms tumor 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq
Other Designations
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- Interactomes
- Diseases
- Publication Reference
- A sporadic case of congenital aniridia caused by pericentric inversion inv(11)(p13q14) associated with a 977 kb deletion in the 11p13 region.
Tatyana A Vasilyeva, Andrey V Marakhonov, Marina E Minzhenkova, Zhanna G Markova, Nika V Petrova, Natella V Sukhanova, Philipp A Koshkin, Denis V Pyankov, Ilya V Kanivets, Sergey A Korostelev, Irina A Krynskaya, Nadezhda V Shilova, Sergey I Kutsev, Vitaly V Kadyshev, Rena A Zinchenko.
BMC Medical Genomics 2020 Sep; 13(Suppl 8):130.
Application：FISH, Human, Human chromosomes.
- A sporadic case of congenital aniridia caused by pericentric inversion inv(11)(p13q14) associated with a 977 kb deletion in the 11p13 region.
WT1 FISH Probe
Referentie FA0275
Formaat : 200uL