6-Hydroxydopamine hydrochloride [28094-15-7]

Biological Activity

6-Hydroxydopamine hydrochloride is an antagonist of the neurotransmitter dopamine.

*The compound is unstable in solutions, freshly prepared is recommended

Product Citations

• 

  Biomater Sci. 2022 Jun 14;10(12):3309-3322.

  Dopamine-derived nanoparticles for the protection of irradiation-induced intestinal injury by maintaining intestinal homeostasis
  6-Hydroxydopamine hydrochloride purchased from AbMole

Protocol (for reference only)

Cell Experiment
Cell lines	MDA-MB-231 and MCF-7 cells
Preparation method	MDA-MB-231 or MCF-7 cells were treated with various concentrations of Liensinine and nuciferine in serum-free media for 24 h.
Concentrations	0 - 60 μM
Incubation time	24 h

Animal Experiment
Animal models	Institute of Cancer Research (ICR) mice
Formulation	The stored solutions of liensinine (1.0 mg/mL) and Midazolam (1.0 mg/mL) were prepared in methanol and water (1:1, v/v)
Dosages	5 mg/kg
Administration	Oral administration

Chemical Information

Molecular Weight	205.64
Formula	(HO)3C6H2CH2CH2NH2.HCl
CAS Number	28094-15-7
Solubility (25°C)	Water: ≥50 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Qian Xu, et al. Effect of Roucongrong (Herba Cistanches Deserticolae) decoction on the substantia nigra through Wnt/β-catenin signaling pathway in rats with Parkinson's disease induced by 6-hydroxydopamine hydrochloride

[2] Monika Pichla, et al. Nitroxide Radical-Containing Redox Nanoparticles Protect Neuroblastoma SH-SY5Y Cells against 6-Hydroxydopamine Toxicity

[3] Wenjie Wang, et al. 6-Hydroxydopamine upregulates iron regulatory protein 1 by activating certain protein kinase C isoforms in the dopaminergic MES23.5 cell line

[4] H Cambridge, et al. Investigation of 6-hydroxydopamine-induced plasma extravasation in rat skin

[5] K J Lookingland, et al. Comparative effects of the neurotoxins N-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP4) and 6-hydroxydopamine on hypothalamic noradrenergic, dopaminergic and 5-hydroxytryptaminergic neurons in the male rat