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> Beauvericin

Beauvericin

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Référence 044598-5mg

Conditionnement : 5mg

Marque : US Biological


044598 Beauvericin

Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

Antibiotic. Apoptosis inducer. Acyl-CoA:cholesterol acyltransferase inhibitor. Anticancer compound. Antihaptotactic and antimetastatic. Antiangiogenic compound. Antibacterial, antiprotozal, antiviral and antifungal compound. Shows ionophoric properties. Cytotoxic. Genotoxic. Potently interacts with ABCB1 and ABCG2 transport functions. Causes mitochondrial dysfunction.

Source:
Beauveria sp.

CAS Number:
26048-05-5

Molecular Weight:
784

Molecular Formula:
C45H57N3O9

Solubility:
Ethanol, methanol or DMSO.

Appearance:
Supplied as a white to off-white solid.

Purity:
≥97% (HPLC)

Storage and Stability:
Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Form
Supplied as a white to off-white solid.
Purity
≥97% (HPLC)
References
Product Reference: |●Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes: D.M. Ojcius, et al.; Exp. Cell Res. 197, 43 (1991)|●Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics: H. Tomoda, et al.; J. Antibiot. (Tokyo) 45, 1626 (1992)|●Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line: D.M. Harnois, et al.; Hepatology 26, 884 (1997)|●Antimycobacterial and antiplasmodial cyclodepsipeptides from the insect pathogenic fungus Paecilomyces tenuipes BCC 1614: C. Nilanonta, et al.; Planta Med. 66, 756 (2000)|●Beauvericin-induced channels in ventricular myocytes and liposomes: K. Kouri, et al.; Biochim. Biophys. Acta. 1609, 203 (2003)|●Cytotoxic effects of the mycotoxin beauvericin to human cell lines of myeloid origin: L. Calò, et al.; Pharmacol. Res. 49, 73 (2004)|●Beauvericin induces cytotoxic effects in human acute lymphoblastic leukemia cells through cytochrome c release, caspase 3 activation: the causative role of calcium: G.M. Jow, et al.; Cancer Lett. 216, 165 (2004)|●Involvement of Bcl-2 family, cytochrome c and caspase 3 in induction of apoptosis by beauvericin in human non-small cell lung cancer cells: H.I. Lin, et al.; Cancer Lett. 230, 248 (2005)|●Induction of calcium influx from extracellular fluid by beauvericin in human leukemia cells: B.F. Chen, et al.; BBRC 340, 134 (2006)|●Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum: J. Zhan, et al.; J. Nat. Prod. 70, 227 (2007)|●An inhibition study of beauvericin on human and rat cytochrome P450 enzymes and its pharmacokinetics in rats: L. Mei, et al.; J. Enzyme Inhib. Med. Chem. 24, 753 (2009)|●Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin: R. Dornetshuber, et al.; Mol. Nutr. Food Res. 53, 904 (2009)|●Beauvericin and enniatins H, I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase: C.G. Shin, et al.; J. Antibiot. (Tokyo) 62, 687 (2009)|●Beauvericin and ochratoxin A genotoxicity evaluated using the alkaline comet assay: single and combined genotoxic action: M.S. Klarić, et al.; Arch. Toxicol. 84, 641 (2010)|●Nematicidal activity of beauvericin produced by the fungus Fusarium bulbicola: A. Shimada, et al.; Z. Naturforsch. C. 65, 207 (2010)|●Beauvericin from the endophytic fungus, Fusarium redolens, isolated from Dioscorea zingiberensis and its antibacterial activity: L. Xu, et al.; Nat. Prod. Commun. 5, 811 (2010)|●The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial dysfunction by affecting the mitochondrial volume regulation, oxidative phosphorylation and ion homeostasis: A.A. Tonshin, et al.; Toxicology 276, 49 (2010)|●Beauvericin induced erythrocyte cell membrane scrambling: S.M. Qadri, et al.; Toxicology 283, 24 (2011)