Cyclic AMP [60-92-4]
Référence TCO2745-1g
Conditionnement : 1g
Marque : TargetMol
Cyclic AMP
(Synonyms: Cyclic 3',5'-monophosphate adenosine, cAMP, Adenosine Cyclophosphate, Adenosine 3',5'-cyclophosphate, 3',5'-AMP) Copy Product Info
Cyclic AMP (cAMP) (Adenosine 3',5'-cyclophosphate) combined with vitamin C treatment of children with viral myocarditis has exact curative effect, and it can improve cardiac function of patients and improve immune function.
Cas No. 60-92-4
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.99%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Introduction
Cyclic AMP AI Summary
Cyclic AMP exhibits a range of bioactivities, including the activation of cAMP-dependent protein kinase type I and II with a binding affinity of K'a = 1.0, and bovine heart protein kinase with Ka of 8.0 M. It has specificity for phosphodiesterases in various tissues, showing Km values of 530.0 nM in bovine heart, 560.0 nM in rabbit lung, and 790.0 nM in rabbit kidney. It also inhibits Phosphodiesterase 7 (Km 200.0 nM), Phosphodiesterase 8 (Km 50.0 nM), and Phosphodiesterase 5 (Km 150,000.0 nM). Additionally, the compound demonstrates inhibitory activity against various viruses, including inhibition rates of 26.0% against L1210 and 34.0% against P388 cell lines, and some antiviral efficacy against Herpes simplex virus-2 strain MS. Furthermore, Cyclic AMP inhibits cAMP phosphodiesterase activities in various tissues with varying Km values and has noted inhibitor effects on alcohol dehydrogenase (Ki 780,000.0 nM). It activates olfactory CNG channels at 3.8 µM and exhibits potency in modulating lamin A splicing (5.0 nM) and other specific protein interactions. The compound inhibits cGMP uptake in membrane vesicles from MRP4 and MRP5-expressing cells, participates in ATP-dependent uptake of cAMP in MRP8-expressing cells, and shows specific inhibition activities against EPAC2 (IC50 40,000.0 nM), Lassa virus, and SARS-CoV-2 3CL-Pro protease at 20µM. Lastly, Cyclic AMP inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells, suggesting potential as an antiviral agent, and binds to GST-tagged EPAC1 CNBD with a Kd of 4500.0 nM, showcasing its diverse bioactivity profile across multiple biological targets..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cyclic AMP (cAMP) (Adenosine 3',5'-cyclophosphate) combined with vitamin C treatment of children with viral myocarditis has exact curative effect, and it can improve cardiac function of patients and improve immune function. |
| Synonyms | Cyclic 3',5'-monophosphate adenosine, cAMP, Adenosine Cyclophosphate, Adenosine 3',5'-cyclophosphate, 3',5'-AMP |
| Molecular Weight | 329.21 |
| Formula | C10H12N5O6P |
| Cas No. | 60-92-4 |
| Smiles | Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O |
| Relative Density. | 2.47 g/cm3 |
| Storage | Store at low temperature,Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 1.65 mg/mL (5.01 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||