Conditionnement : 200mg
Synonyms: L-α-Dimyristoylphosphatidylglycerol, 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol
| Description | DMPG (L-α-Dimyristoylphosphatidylglycerol; 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol) is a type of phospholipid utilized in the synthesis of formulations like liposomes or gels. It is also employed in research related to drug delivery. |
| In vitro | DMPG is known to have a wide gel-to-fluid transition range, spanning from 18 to 35 ℃. |
| In vivo | DMPG (1.6-4.8 mg/kg; intravenous injection; single dose) displays formulation-dependent elimination kinetics: when administered as an amphotericin B lipid complex suspension, its half-life extends to 4.6-8.1 hours, compared to a half-life of 1.1-2.3 hours when given alone. Additionally, at all tested doses, both C max and AUC 0-t increase proportionally with the dose, with preferential tissue accumulation observed in the lungs, liver, spleen, and kidneys. |
| Synonyms | L-α-Dimyristoylphosphatidylglycerol, 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol |
| Molecular Weight | 666.86 |
| Formula | C34H67O10P |
| Cas No. | 185463-22-3 |
| Smiles | [C@@H](COP(OCC(CO)O)(=O)O)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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