EBAG9 Mouse Monoclonal Antibody [Clone ID: 22-1-1]
Specifications
Product Data | |
Clone Name | 22-1-1 |
Applications | FC, IHC |
Recommended Dilution | Flow cytometry: 1 - 5 μg/ml. |
Reactivities | Human |
Host | Mouse |
Isotype | IgM |
Clonality | Monoclonal |
Immunogen | Human uterine cervical adenocarcinoma cell |
Specificity | This antibody recognizes RCAS1. |
Formulation | 100 ug IgG in 100 uL volukme of PBS containing 50% glycerol and 0.5M NaCl, pH 7.2 No preservative is contained. State: Azide Free State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-L Sepharose |
Conjugation | Unconjugated |
Storage | Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | estrogen receptor binding site associated, antigen, 9 |
Database Link | |
Background | RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is a novel tumoreassociated antigen expressed in human uterine and ovarian carcinomas. The predicted amino acid sequence of RCAS1 (213 a.a.) possesses an N-terminal transmembrane region and a coiled-coil structure in the C-terminal portion, indicating that RCAS1 is a type II membrane protein able to form oligomers through the coiled-coil structure. RCAS1 revealed different expression pattern from the known tumore associated antigens such as, YH206, GA733, CA125, CEA and sialyl Le molecules in human tumore cell lines. Recent study indicated RCAS1 acts as a ligand for a putative receptor present on various human cells including T, B and NK cells. RCAS1 inhibited the in vitro growth of receptor-expressing cells and induced apoptosis. It was suggested that tumore cells might evade immune surveillance by expression of RCAS1. |
Synonyms | EB9, PDAF |
Note | This product was originally produced by MBL International. Protocol: Preparation for Flowcytometric analysis Immunohistochemical staining |
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