Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Gentamicin sulfate [1405-41-0]

Imprimer

Référence NB-64-04816-500mg

Conditionnement : 500mg

Marque : Neo Biotech

Demander plus d'informations

Remove All

Gentamicin sulfate

(Synonyms: SCH9724, NSC-82261, Gentamycin sulfate) Copy Product Info

Synonyms: SCH9724, NSC-82261, Gentamycin sulfate

Catalog No. T1326 Copy Product Info

Purity: 99.93%

Gentamicin sulfate (SCH9724) is a broad-spectrum, orally administered aminoglycoside antibiotic that exhibits inhibitory activity against aerobic Gram-negative bacteria by interfering with mRNA translation.

Cas No. 1405-41-0

For research use only—not for human use. No sales to individuals. Use as intended only.

Select Batch

Purity:99.93%

Potency:≥590IU/mg

Color:White to Yellow

Product Introduction

Bioactivity

Description	Gentamicin sulfate (SCH9724) is a broad-spectrum, orally administered aminoglycoside antibiotic that exhibits inhibitory activity against aerobic Gram-negative bacteria by interfering with mRNA translation.
Targets & IC50	Streptococcus faecalis:< 40 μg/mL, DNase I:0.57 mM, MDCK cells:32 mM
In vitro	METHODS: Fibroblasts, MDCK and LLC-PK1 cells were treated with Gentamicin sulfate (0-3 mM) for 4 days and apoptosis was detected by TUNEL assay. RESULTS: The incidence of apoptosis was increased in all 3 cell lines, correlating almost directly with the extracellular concentration of Gentamicin sulfate and the incubation time, reaching 20-30% of all cells. [1]
In vivo	Gentamicin is the first choice aminoglycoside for the treatment of serious infections at present, with alternatives being amikacin, netilmicin, and tobramycin. Gentamicin preparations are commercially available in three forms, namely otic, ophthalmic, and topical based on the respective function to treat infections of ear canal, eye, and skin. Oral and injectable forms of gentamicin are found to exhibit effective antibacterial activity against Yersinia pestis as demonstrated in a mouse infection model[4]. Treatment with up to nine doses of methicillin or gentamicin shows an obvious reduction of bacteria on the foreign body[5].
Synonyms	SCH9724, NSC-82261, Gentamycin sulfate

Chemical Properties

Molecular Weight	1488.79
Formula	C₆₀H₁₂₅N₁₅O₂₅S
Cas No.	1405-41-0
Smiles	CC([C@@H]1CC[C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)N)N)N)N.CC([C@@H]1CC[C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)N)N)N)NC.C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H](CC[C@H](O3)CN)N)N)N)O.OS(=O)(=O)O
Relative Density.	1.000 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 255.00 mg/mL (171.28 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.6717 mL	3.3584 mL	6.7169 mL	33.5843 mL
5 mM	0.1343 mL	0.6717 mL	1.3434 mL	6.7169 mL
10 mM	0.0672 mL	0.3358 mL	0.6717 mL	3.3584 mL
20 mM	0.0336 mL	0.1679 mL	0.3358 mL	1.6792 mL
50 mM	0.0134 mL	0.0672 mL	0.1343 mL	0.6717 mL
100 mM	0.0067 mL	0.0336 mL	0.0672 mL	0.3358 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

SCH-9724SCH 9724orally activeNSC82261NSC 82261Meniere's diseaseInhibitorinhibitglandular tularemiaGentamycin SulfateGentamicin sulfateGentamicinDNase IDHFRBacterialAntibiotic30S ribosome16S ribosome

Related Tags: Gentamicin sulfate chemical structure | Gentamicin sulfate in vivo | Gentamicin sulfate in vitro | Gentamicin sulfate formula | Gentamicin sulfate molecular weight