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> Geranyl acetate [105-87-3]

Geranyl acetate [105-87-3]

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Référence orb1909035-25g

Conditionnement : 25g

Marque : Biorbyt


Geranyl acetate

SKU: orb1909035

Description

Geranyl acetate, a monoterpene ester identified in Cannabis sativa, exhibits a range of biological activities. It is utilized in research areas such as phytochemistry and pharmacology for in vitro studies investigating its potential bioactive properties.

Research Area

Cell Biology

Images & Validation

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Geranyl acetate

Key Properties

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CAS Number105-87-3
MW196.29
Purity98.00% (May vary between batches)
FormulaC12H20O2
SMILESCC(C)=CCCC(C)=CCOC(C)=O
TargetApoptosis
SolubilityDMSO:250 mg/mL (1273.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.19 mM)

Bioactivity

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In Vitro
Studies on the antifungal activity especially Microsporum gypsum, Trichophyton vercossum and Candida tropicalis showed that geranyl acetate, its epoxide and hydroperoxide derivatives have good antifungal action.Geranyl acetate exhibited significant anticancer activity against colo-205 cancer cell line with IC50 values of 30 μM . To find out the underlying mechanism, DAPI staining was carried out and it was observed that both the monoterpenes, geraniol and geranyl acetate, induced apoptosis in colo-205 cells. The apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expressions, indicative of mitochondrial apoptosis. Moreover, this monoterpenes could trigger DNA damage and G2/M cell cycle arrest in colo-205 cells.
Cell Research
The antiproliferative activity was determined by MTT assay. Apoptosis was assessed by DAPI staining and DNA damage was checked by comet assay. The cell cycle analysis was carried out by flow cytometry and protein expression was examined by western blotting..

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Apoptosis, Inhibitor, Geranyl, Geranyl acetate, Geranyl Acetate, inhibit
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  • 8-Hydroxygeraniol

    8-Hydroxygeraniol [orb3136977]

    26488-97-1

    170.25

    C10H18O2

    10 mg, 1 mg, 5 mg, 100 mg, 25 mg, 50 mg
  • Neryl acetate

    Neryl acetate [orb1297730]

    97.15% (May vary between batches)

    141-12-8

    196.29

    C12H20O2

    1 ml x 10 mM (in DMSO)

Compound Identifiers

PubChem CID
7780 ↗

Key Properties

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No computed properties available.

Protocol Information