Orb1909035-25g | Geranyl acetate [105-87-3] Clinisciences

Geranyl acetate

SKU: orb1909035

Description

Geranyl acetate, a monoterpene ester identified in Cannabis sativa, exhibits a range of biological activities. It is utilized in research areas such as phytochemistry and pharmacology for in vitro studies investigating its potential bioactive properties.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	105-87-3
MW	196.29
Purity	98.00% (May vary between batches)
Formula	C₁₂H₂₀O₂
SMILES	CC(C)=CCCC(C)=CCOC(C)=O
Target	Apoptosis
Solubility	DMSO:250 mg/mL (1273.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.19 mM)

Bioactivity

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In Vitro	Studies on the antifungal activity especially Microsporum gypsum, Trichophyton vercossum and Candida tropicalis showed that geranyl acetate, its epoxide and hydroperoxide derivatives have good antifungal action.Geranyl acetate exhibited significant anticancer activity against colo-205 cancer cell line with IC50 values of 30 μM . To find out the underlying mechanism, DAPI staining was carried out and it was observed that both the monoterpenes, geraniol and geranyl acetate, induced apoptosis in colo-205 cells. The apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expressions, indicative of mitochondrial apoptosis. Moreover, this monoterpenes could trigger DNA damage and G2/M cell cycle arrest in colo-205 cells.
Cell Research	The antiproliferative activity was determined by MTT assay. Apoptosis was assessed by DAPI staining and DNA damage was checked by comet assay. The cell cycle analysis was carried out by flow cytometry and protein expression was examined by western blotting..

In Vitro

Studies on the antifungal activity especially Microsporum gypsum, Trichophyton vercossum and Candida tropicalis showed that geranyl acetate, its epoxide and hydroperoxide derivatives have good antifungal action.Geranyl acetate exhibited significant anticancer activity against colo-205 cancer cell line with IC50 values of 30 μM . To find out the underlying mechanism, DAPI staining was carried out and it was observed that both the monoterpenes, geraniol and geranyl acetate, induced apoptosis in colo-205 cells. The apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expressions, indicative of mitochondrial apoptosis. Moreover, this monoterpenes could trigger DNA damage and G2/M cell cycle arrest in colo-205 cells.

Cell Research

The antiproliferative activity was determined by MTT assay. Apoptosis was assessed by DAPI staining and DNA damage was checked by comet assay. The cell cycle analysis was carried out by flow cytometry and protein expression was examined by western blotting..

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, Inhibitor, Geranyl, Geranyl acetate, Geranyl Acetate, inhibit

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Compound Identifiers

PubChem CID

7780 ↗

Key Properties

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Geranyl acetate (orb1909035)

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Geranyl acetate [105-87-3]

Référence orb1909035-25g

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Geranyl acetate

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Geranyl acetate (orb1909035)

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