Orb1219087-10mg | Isolongifolene [1135-66-6] Clinisciences

Isolongifolene

SKU: orb1219087

Description

Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Isolongifolene is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways.

Images & Validation

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Key Properties

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CAS Number	1135-66-6
MW	204.35
Purity	>98% (HPLC)
Formula	C₁₅H₂₄
SMILES	CC1(C)[C@]23CC[C@](C3)(00)C(C)(C)C2=CCC1
Target	Others
Solubility	DMSO:10 mM

Bioactivity

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In Vitro	Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene. Cell Viability Assay Cell line: SH-SY5Y neuroblastoma cells. Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM Incubation time: 26 hours. Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. Apoptosis Analysis Cell line: SH-SY5Y neuroblastoma cells. Concentration: 10 μM. Incubation time: 26 hours. Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. Western blot analysis. Cell line: SH-SY5Y neuroblastoma cells. Concentration: 10 μM. Incubation time: 26 hours. Result: Attenuated rotenone induced toxicity by down-regulatingBax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.

In Vitro

Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene. Cell Viability Assay Cell line: SH-SY5Y neuroblastoma cells. Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM Incubation time: 26 hours. Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. Apoptosis Analysis Cell line: SH-SY5Y neuroblastoma cells. Concentration: 10 μM. Incubation time: 26 hours. Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. Western blot analysis. Cell line: SH-SY5Y neuroblastoma cells. Concentration: 10 μM. Incubation time: 26 hours. Result: Attenuated rotenone induced toxicity by down-regulatingBax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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(-)-Isolongifolene

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Isolongifolene [orb1709393]
Purity:
90.13% (May vary between batches)
CAS Number:
1135-66-6
MW:
204.35
Formula:
C₁₅H₂₄
Sizes Available: 5 mg, 1 mg, 10 mg, 25 mg, 1 ml x 10 mM (in DMSO)

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Gene Symbol

Others

Isolongifolene [1135-66-6]

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