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Maytansine [35846-53-8]

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Référence NB-64-10907-5mg

Conditionnement : 5mg

Marque : Neo Biotech

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Maytansine

(Synonyms: NSC-153858, NSC153858, NSC 153858, Maitansine, Maitansina) Copy Product Info

Synonyms: NSC-153858, NSC153858, NSC 153858, Maitansine, Maitansina

Catalog No. T21351 Copy Product Info

Purity: 99.62%

Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.

Cas No. 35846-53-8

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.62%

Appearance:Solid

Color:White

Product Information

Maytansine AI Summary

Maytansine exhibits a range of bioactivities, effectively targeting multiple pathways and viruses. It inhibits Nrf2 with a potency of 517.4 nM and demonstrates cytotoxicity against VEEV compounds with a CC50 of less than 50.0 nM. This compound also inhibits Lassa Virus binding or entry into cells with a potency of 141.3 nM and blocks Hepatitis C Virus (HCV) activity at 2818.4 nM. It remarkably inhibits ATXN expression with a potency of 6.7 nM. Additionally, it induces synthetic lethality in tumor cells producing 2HG in the HT-1080-IDH1KD cell line at 32642.7 nM and in the HT-1080-NT fibrosarcoma cell line at 4.1 nM. For human tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibition, it shows a potency of 130.0 nM in the absence of CPT and 46.1 nM in the presence of CPT. Lastly, it serves as a stage-specific inhibitor of Vaccinia Orthopoxvirus with a potency of 3548.1 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
Synonyms	NSC-153858, NSC153858, NSC 153858, Maitansine, Maitansina

Chemical Properties

Molecular Weight	692.2
Formula	C₃₄H₄₆ClN₃O₁₀
Cas No.	35846-53-8
Smiles	01[C@@]12O[C@@]1(C)[C@H](CC(=O)N(C)c1cc(C\C(C)=C/C=C\[C@@H](OC)[C@@]3(O)C[C@](01)(OC(=O)N3)[C@H]2C)cc(OC)c1Cl)OC(=O)[C@H](C)N(C)C(C)=O
Relative Density.	1.1049 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 75 mg/mL (108.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 7.5 mg/mL (10.84 mM), Suspension.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4447 mL	7.2233 mL	14.4467 mL	72.2335 mL
5 mM	0.2889 mL	1.4447 mL	2.8893 mL	14.4467 mL
10 mM	0.1445 mL	0.7223 mL	1.4447 mL	7.2233 mL
20 mM	0.0722 mL	0.3612 mL	0.7223 mL	3.6117 mL
50 mM	0.0289 mL	0.1445 mL	0.2889 mL	1.4447 mL
100 mM	0.0144 mL	0.0722 mL	0.1445 mL	0.7223 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

tumorsubnanomolarpotentmitoticmicrotubule-targetedMicrotubuleAssociatedMicrotubule/TubulinMicrotubule AssociatedmicrotubuleMaytansineInhibitorinhibitarrestAntibiotic

Related Tags: Maytansine chemical structure | Maytansine formula | Maytansine molecular weight