Conditionnement : 50mg
Synonyms:
| Description | Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active, and selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 1.33 nM, capable of crossing the blood-brain barrier (BBB). It exhibits antioxidant and anti-neuroinflammatory activities and is useful in the study of Parkinson's disease [1]. |
| Targets & IC50 | MAO-A:1150 nM, MAO-B:1.33 nM |
| In vitro | In cellular assays, Monoamine Oxidase B Inhibitor 2 (compound 8f; concentration range: 0.5-10.0 μM) markedly reduced the levels of NO and TNF-α in LPS-induced BV-2 cells [1]. |
| In vivo | In an in vivo acute and subacute MPTP-induced mouse model of Parkinson’s disease, Monoamine Oxidase B inhibitor 2 (compound 8f; 6.3-39.5 mg/kg; orally administered) significantly ameliorated most behavioral disorders, restored dopamine levels, and reduced MDA content in the striatum of mice [1]. |
| Molecular Weight | 314.35 |
| Formula | C19H19FO3 |
| Smiles | #N/A |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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