Mouse Monoclonal Anti-MUC1 / EMA / CD227 (Epithelial Marker) [Clone MUC1/967]
Référence NB-36-00521-P1ABX
Conditionnement : 100ug
Marque : Neo Biotech
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MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker) Antibody [MUC1/967]
Applications & Dilutions
Summary
This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein.The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.
Product Properties & Targets
Functions
- The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
- The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Key References
- Stanley CM, Phillips TE. Am J Physiol. 1999;277:G191-200.
PubMed Links
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- https://pubmed.ncbi.nlm.nih.gov/11173916/
- https://pubmed.ncbi.nlm.nih.gov/11118479/
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- https://pubmed.ncbi.nlm.nih.gov/11350974/
- https://pubmed.ncbi.nlm.nih.gov/11483589/
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- https://pubmed.ncbi.nlm.nih.gov/12441351/
- https://pubmed.ncbi.nlm.nih.gov/12832415/
- https://pubmed.ncbi.nlm.nih.gov/12939402/
- https://pubmed.ncbi.nlm.nih.gov/15471854/
- https://pubmed.ncbi.nlm.nih.gov/15710329/
- https://pubmed.ncbi.nlm.nih.gov/16288032/
- https://pubmed.ncbi.nlm.nih.gov/15972891/
- https://pubmed.ncbi.nlm.nih.gov/15513966/
- https://pubmed.ncbi.nlm.nih.gov/16507569/
- https://pubmed.ncbi.nlm.nih.gov/16427018/
- https://pubmed.ncbi.nlm.nih.gov/17524503/
- https://pubmed.ncbi.nlm.nih.gov/17308127/
- https://pubmed.ncbi.nlm.nih.gov/17545600/
- https://pubmed.ncbi.nlm.nih.gov/16983337/
- https://pubmed.ncbi.nlm.nih.gov/20816948/
- https://pubmed.ncbi.nlm.nih.gov/23186163/
- https://pubmed.ncbi.nlm.nih.gov/23396133/
- https://pubmed.ncbi.nlm.nih.gov/16585136/
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