Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sitagliptin phosphate monohydrate [654671-77-9]
Référence T0242L-100mg
Conditionnement : 100mg
Marque : TargetMol
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Sitagliptin phosphate monohydrate
Catalog No. T0242L CAS 654671-77-9
Synonyms: MK-0431, MK-0431 phosphate monohydrate
Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
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Sitagliptin phosphate monohydrate, CAS 654671-77-9
| Description | Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts. |
| Targets&IC50 | DPP4:19 nM |
| In vitro | The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively. [1] Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. [2]Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. [3] |
| Synonyms | MK-0431, MK-0431 phosphate monohydrate |
| Molecular Weight | 523.32 |
| Formula | C16H15F6N5O·H3PO4·H2O |
| CAS No. | 654671-77-9 |
Storage
Solubility Information
H2O: 38 mg/mL (72.6 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (177.7 mM)
References and Literature
1. Thomas L et al. J Pharmacol Exp Ther. 2008; 325(1): 175-182. 2. Kim SJ et al. Diabetes. 2009; 58(3): 641-651.
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Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Keywords
Sitagliptin phosphate monohydrate 654671-77-9 Autophagy Proteases/Proteasome Ubiquitination Proteasome DPP-4 MK 0431 Phosphate Inhibitor DPP MK0431 MK-0431 Phosphate Sitagliptin Phosphate MK-0431 MK 0431 MK-0431 phosphate Sitagliptin phosphate Sitagliptin phosphate Monohydrate MK-0431 phosphate monohydrate MK0431 Phosphate inhibit Dipeptidyl Peptidase MK-0431 phosphate Monohydrate inhibitor