Tetradecylphosphonic acid [4671-75-4]
Référence HY-132238-100mg
Conditionnement : 100mg
Marque : MedChemExpress
| Description |
Tetradecylphosphonic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
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| Cellular Effect |
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| In Vitro |
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors. The IC50 value for inhibition of LPA-induced calcium mobilization was 10 μM, 5.5 μM, and 3.1 μM, respectively. At a concentration of 10 μM, tetradecyl phosphonate activates a peroxisome proliferator-activated receptor γ reporter construct 4-fold when compared with the controls and partially inhibits autotaxin with an IC50 value of approximately 3 μM. Lysophosphatidic acid (LPA) , also known as autotaxin (ATX ), is a lipid signaling molecule formed by the hydrolysis of lysophosphatidyl choline by lysophospholipase D. LPA signals through four different G protein-coupled receptors, named as LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7, and LPA4/GPR23 . It has been reported that LPA was involved in activating peroxisome proliferator-activated receptor γ (PPARγ) . MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |