Orb1220374-5mg | Thyrotropin-Releasing Hormone (TRH) Free Acid [24769

Thyrotropin-Releasing Hormone (TRH) Free Acid

SKU: orb1220374

Description

Thyrotropin-Releasing Hormone (TRH) Free Acid (TRH-OH) causes a variety of thyroidal and non-thyroidal effects the best known being the feedback regulation of thyroid hormone levels.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	24769-58-2
MW	363.37
Purity	>98% (HPLC)
Formula	C₁₆H₂₁N₅O₅
SMILES	O=C1CCC(C(=O)NC(Cc2c[nH]cn2)C(=O)N2CCCC2C(=O)O)N1
Target	Others
Solubility	In Vitro: H2O : 100 mg/mL (275.20 mM)

Bioactivity

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In Vitro	TRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions. TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [3H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na+ channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na+ current amplitude is reduced by 20-50%.

In Vitro

TRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions. TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [3H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na+ channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na+ current amplitude is reduced by 20-50%.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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TRH-OH

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Thyrotropin-Releasing Hormone (TRH), Free Acid [orb1299848]
Purity:
≥95% (May vary between batches)
MW:
363.37
Sizes Available: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
TRH, Free Acid [orb2694967]
Purity:
≥95%
MW:
363.4
Sizes Available: 5 mg, 10 mg

Quick Database Links

Gene Symbol

Others

Thyrotropin-Releasing Hormone (TRH) Free Acid [24769-58-2]

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