Viomycin [32988-50-4]

Référence 505530-10mg

Conditionnement : 10mg

Marque : US Biological



505530 Viomycin

Shipping Temp
RT
Storage Temp
-20°C

Member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state.
Facilitates trans-cleavage of the Neurospora VS ribozyme.

Synonyms:
(S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate

CAS Number:
32988-50-4

Molecular Formula:
C25H43N13O10.4½H2O

Molecular Weight:
962.92

Appearance:
Supplied as an off-white solid.

Analysis by Mass Spectrum:
Conforms to standard

Analysis by H-NMR:
Conforms to structure

Solubility:
Water to 75mM

Storage and Stability:
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Form
Supplied as an off-white solid.
References
1. Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263: 13103. PMID: 2843509.|2. Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19: 1. PMID: 10619838.|3. Ermolenko et al (2007) The antibiotic viomycin traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14: 493. PMID: 17515906.

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