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Z-Glycine [1138-80-3]

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Référence NB-64-21636-5g

Conditionnement : 5g

Marque : Neo Biotech

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Z-Glycine (Synonyms: N-Carbobenzoxyglycine, Carbobenzoxyglycine)

Catalog No. T33604 Copy Product Info

Purity: 99.88%

Z-Glycine (Carbobenzoxyglycine) is a drug-lipid conjugates designed to promote brain penetration based on its lipophilicity and resemblance to lipids in biological membranes[1].

Z-Glycine

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Synonyms N-Carbobenzoxyglycine, Carbobenzoxyglycine

Z-Glycine (Carbobenzoxyglycine) is a drug-lipid conjugates designed to promote brain penetration based on its lipophilicity and resemblance to lipids in biological membranes[1].

Cas No. 1138-80-3

Batch Information

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Purity:99.88%

Appearance:solid

Color:White

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COA HNMR HPLC

Product Introduction

Z-Glycine AI Summary

Z-Glycine exhibits a range of biological activities and pharmacological effects. It demonstrates bioactivity in a papain-catalyzed hydrolysis assay with a Km value of 10,300 nM. Additionally, it shows significant anticonvulsant activity in various seizure models in mice, including maximal electroshock seizures and seizures induced by strychnine and 3-mercaptopropionic acid, suggesting its potential for managing neurological conditions associated with seizures. The compound also stimulates oxygen consumption activity of rat recombinant peptidylglycine alpha-amidating monooxygenase, with a Km value of 590,000 nM and a Vmax(app) value of 8.6/s, with a Vm(app) to Km(app) ratio of 1.5 x 10^4/M/s. Relative to hippuric acid, its activity is 2.4. In oncology studies, Z-Glycine exhibits antineoplastic activity against mouse EAC allografts in CF1 mice, significantly impacting packed cell volume and ascites volume, and achieving a high tumor growth inhibition rate of 97.0% on day 7 at a dose of 33 mg/kg. However, in the NAAA assay, the compound shows a weak or negligible inhibitory effect on N-acylethanolamine acid amidase (NAAA), with an IC50 value exceeding 100,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Z-Glycine (Carbobenzoxyglycine) is a drug-lipid conjugates designed to promote brain penetration based on its lipophilicity and resemblance to lipids in biological membranes[1].
Synonyms	N-Carbobenzoxyglycine, Carbobenzoxyglycine

Chemical Properties

Molecular Weight	209.2
Formula	C₁₀H₁₁NO₄
Cas No.	1138-80-3
Smiles	OC(=O)CNC(=O)OCC1=CC=CC=C1
Relative Density.	1.2944 g/cm3 (Estimated)
Sequence	Cbz-Gly-OH
Sequence Short	G

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (262.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7801 mL	23.9006 mL	47.8011 mL	239.0057 mL
5 mM	0.9560 mL	4.7801 mL	9.5602 mL	47.8011 mL
10 mM	0.4780 mL	2.3901 mL	4.7801 mL	23.9006 mL
20 mM	0.2390 mL	1.1950 mL	2.3901 mL	11.9503 mL
50 mM	0.0956 mL	0.4780 mL	0.9560 mL	4.7801 mL
100 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.