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(±)-α-Bisabolol [515-69-5]

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Referência NB-64-85294-1mL

Tamanho : 1mL

Marca : Neo Biotech

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(±)-α-Bisabolol (Synonyms: Bisabolol)

Catalog No. T8199 Copy Product Info

(±)-α-Bisabolol (Bisabolol) isa sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, antiirritating, anti-inflammatory, antioxidant and anticancer activities. (±)-α-Bisabolol has anticancer effects on A549 NSC-LC cells by inducing cell cycle arrest, mitochondrial death and inhibiting PI3K/Akt signaling (IC50 = 15 μM). (±)-α-Bisabolol can induce apoptosis of glioma cells.

(±)-α-Bisabolol

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Synonyms Bisabolol

Cas No. 515-69-5

Batch Information

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Appearance:Liquid

Color:Transparent

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	(±)-α-Bisabolol (Bisabolol) isa sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, antiirritating, anti-inflammatory, antioxidant and anticancer activities. (±)-α-Bisabolol has anticancer effects on A549 NSC-LC cells by inducing cell cycle arrest, mitochondrial death and inhibiting PI3K/Akt signaling (IC50 = 15 μM). (±)-α-Bisabolol can induce apoptosis of glioma cells.
Targets&IC50	PI3K/Akt:15 μM
In vitro	Under resting tonus, (–)-a-bisabolol (30–300 µmol/L) relaxed duodenal strips. Contracting endothelium-intact aortic rings and urinary bladder strips, and relaxing these tissues at higher concentrations (600–1000 µmol/L). In preparations precontracted either electromechanically (by 60 mmol/L K+) or pharmacomechanically (by phenylephrine or carbachol), (–)-a-bisabolol showed only relaxing properties. [1]
In vivo	(-)-α-Bisabolol (100-200 mg/kg; p.o.; one day before and 1 h after pMCAO; once daily for the following five days; mice) significantly reduces the infarcted area and neurological deficits caused by pMCAO. (−)-α-bisabolol can exert anti-inflammatory effects by reducing astrogliosis, MPO activity, and TNF-α and iNOS production.[1] (–)-a-bisabolol attenuated the increased responses of carbachol in tracheal rings of ovalbumin-sensitized rats challenged with ovalbumin, but was without effect in the decreased responsiveness of urinary bladder strips in mice treated with ifosfamide. (–)-a-bisabolol may be an inhibitor of voltage-dependent Ca2+ channels.[2]
Synonyms	Bisabolol

Chemical Properties

Molecular Weight	222.37
Formula	C₁₅H₂₆O
Cas No.	515-69-5
Smiles	CC(C)=CCCC(C)(O)C1CCC(C)=CC1
Relative Density.	0.93 g/mL at 20°C(lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (404.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (14.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4970 mL	22.4850 mL	44.9701 mL	224.8505 mL
5 mM	0.8994 mL	4.4970 mL	8.9940 mL	44.9701 mL
10 mM	0.4497 mL	2.2485 mL	4.4970 mL	22.4850 mL
20 mM	0.2249 mL	1.1243 mL	2.2485 mL	11.2425 mL
50 mM	0.0899 mL	0.4497 mL	0.8994 mL	4.4970 mL
100 mM	0.0450 mL	0.2249 mL	0.4497 mL	2.2485 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.