Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.
 
> (E,​E)​-​Farnesol [106-28-5]

(E,​E)​-​Farnesol [106-28-5]

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Referência HY-Y0248-10g

Tamanho : 10g

Marca : MedChemExpress


Description

(E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
40 μM
Compound: Farnesol
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method
[PMID: 21030469]
HEK293 IC50
47 μM
Compound: Farnesol
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method
[PMID: 21030469]
In Vitro

(E,​E)-Farnesol (0-1 mM; 0-48 h) can inhibit the growth of most Candida species, with C. tropicalis being the most sensitive, as well as inhibit metabolism and biofilm formation[1].
(E, E)-Farnesol (50 µM; 30 days) in C. albicans ATCC 90028, long-term treatment inhibits yeast-to-hyphal transition, with the percentage of blastospores exceeding 90%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E,​E)​-​Farnesol Related Antibodies

Solvant et solubilité
In Vitro: 

DMSO : ≥ 100 mg/mL (449.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4970 mL 22.4850 mL 44.9701 mL
5 mM 0.8994 mL 4.4970 mL 8.9940 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références