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> 6'-Sialyllactose [35890-39-2]

6'-Sialyllactose [35890-39-2]

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Referência T75519-1mg

Tamanho : 1mg

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6'-Sialyllactose

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6'-Sialyllactose (6'-SL) is one of the most predominant human milk oligosaccharides (HMOs) with significant prebiotic activity, promoting the growth of beneficial bacteria (e.g., Bifidobacterium and Lactobacillus) while inhibiting harmful pathogens. 6'-SL exhibits pleiotropic biological activities: it diminishes stress-induced anxiety via the gut-brain axis, ameliorates benign prostatic hyperplasia by suppressing VEGF-mediated angiogenesis (via Akt-ERK inhibition), and enhances exercise performance by increasing muscle mass and strength. It also reduces the internalization of Pseudomonas aeruginosa in human pneumocytes.
6'-Sialyllactose
Cas No. 35890-39-2
Other Forms of 6'-Sialyllactose:
6'-Sialyllactose Sodium SaltT37347157574-76-0
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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%
Appearance:Solid
Color:White

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Description
6'-Sialyllactose (6'-SL) is one of the most predominant human milk oligosaccharides (HMOs) with significant prebiotic activity, promoting the growth of beneficial bacteria (e.g., Bifidobacterium and Lactobacillus) while inhibiting harmful pathogens. 6'-SL exhibits pleiotropic biological activities: it diminishes stress-induced anxiety via the gut-brain axis, ameliorates benign prostatic hyperplasia by suppressing VEGF-mediated angiogenesis (via Akt-ERK inhibition), and enhances exercise performance by increasing muscle mass and strength. It also reduces the internalization of Pseudomonas aeruginosa in human pneumocytes.
In vitro
6'-Sialyllactose (0–50 μM, 24 h) inhibits DHT-induced HUVEC proliferation and tube formation by downregulating p-Akt/p-ERK and blocking VEGFR-2 signaling. It also reduces Pseudomonas aeruginosa internalization in human pneumocyte models [1][4].
In vivo
In vivo, supplementing mouse diets with 5% 6'-Sialyllactose for 2 weeks significantly diminishes stressor-induced anxiety-like behavior and maintains the number of DCX-positive cells in the hippocampus [2]. In muscle health studies, oral administration of 6'-SL (100 mg/kg, 12 weeks) increases muscle mass and strength, leading to improved exercise endurance [3]. Furthermore, it effectively ameliorates benign prostatic hyperplasia in mice by suppressing angiogenesis [4]
Chemical Properties
Molecular Weight633.55
FormulaC23H39NO19
Cas No.35890-39-2
SmilesO(C[C@H]1O[C@@H](O[C@@H]([C@@H]([C@H](C=O)O)O)[C@@H](CO)O)[C@H](O)[C@@H](O)[C@H]1O)[C@@]2(C(O)=O)O[C@@]([C@@H]([C@@H](CO)O)O)([C@H](NC(C)=O)[C@@H](O)C2)01
Storage & Solubility Information
StorageKeep away from moisture,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Related Tags: 6'-Sialyllactose chemical structure | 6'-Sialyllactose in vivo | 6'-Sialyllactose in vitro | 6'-Sialyllactose formula | 6'-Sialyllactose molecular weight
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