6'-Sialyllactose [35890-39-2]
Referência T75519-100mg
Tamanho : 100mg
Marca : TargetMol
6'-Sialyllactose
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6'-Sialyllactose (6'-SL) is one of the most predominant human milk oligosaccharides (HMOs) with significant prebiotic activity, promoting the growth of beneficial bacteria (e.g., Bifidobacterium and Lactobacillus) while inhibiting harmful pathogens. 6'-SL exhibits pleiotropic biological activities: it diminishes stress-induced anxiety via the gut-brain axis, ameliorates benign prostatic hyperplasia by suppressing VEGF-mediated angiogenesis (via Akt-ERK inhibition), and enhances exercise performance by increasing muscle mass and strength. It also reduces the internalization of Pseudomonas aeruginosa in human pneumocytes.
Cas No. 35890-39-2
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.97%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | 6'-Sialyllactose (6'-SL) is one of the most predominant human milk oligosaccharides (HMOs) with significant prebiotic activity, promoting the growth of beneficial bacteria (e.g., Bifidobacterium and Lactobacillus) while inhibiting harmful pathogens. 6'-SL exhibits pleiotropic biological activities: it diminishes stress-induced anxiety via the gut-brain axis, ameliorates benign prostatic hyperplasia by suppressing VEGF-mediated angiogenesis (via Akt-ERK inhibition), and enhances exercise performance by increasing muscle mass and strength. It also reduces the internalization of Pseudomonas aeruginosa in human pneumocytes. |
| In vitro | 6'-Sialyllactose (0–50 μM, 24 h) inhibits DHT-induced HUVEC proliferation and tube formation by downregulating p-Akt/p-ERK and blocking VEGFR-2 signaling. It also reduces Pseudomonas aeruginosa internalization in human pneumocyte models [1][4]. |
| In vivo | In vivo, supplementing mouse diets with 5% 6'-Sialyllactose for 2 weeks significantly diminishes stressor-induced anxiety-like behavior and maintains the number of DCX-positive cells in the hippocampus [2]. In muscle health studies, oral administration of 6'-SL (100 mg/kg, 12 weeks) increases muscle mass and strength, leading to improved exercise endurance [3]. Furthermore, it effectively ameliorates benign prostatic hyperplasia in mice by suppressing angiogenesis [4] |
| Molecular Weight | 633.55 |
| Formula | C23H39NO19 |
| Cas No. | 35890-39-2 |
| Smiles | O(C[C@H]1O[C@@H](O[C@@H]([C@@H]([C@H](C=O)O)O)[C@@H](CO)O)[C@H](O)[C@@H](O)[C@H]1O)[C@@]2(C(O)=O)O[C@@]([C@@H]([C@@H](CO)O)O)([C@H](NC(C)=O)[C@@H](O)C2)08 |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |