Tamanho : 25mg
Synonyms:
| Description | 6'-Sialyllactose (6'-SL) is one of the most predominant human milk oligosaccharides (HMOs) with significant prebiotic activity, promoting the growth of beneficial bacteria (e.g., Bifidobacterium and Lactobacillus) while inhibiting harmful pathogens. 6'-SL exhibits pleiotropic biological activities: it diminishes stress-induced anxiety via the gut-brain axis, ameliorates benign prostatic hyperplasia by suppressing VEGF-mediated angiogenesis (via Akt-ERK inhibition), and enhances exercise performance by increasing muscle mass and strength. It also reduces the internalization of Pseudomonas aeruginosa in human pneumocytes. |
| In vitro | 6'-Sialyllactose (0–50 μM, 24 h) inhibits DHT-induced HUVEC proliferation and tube formation by downregulating p-Akt/p-ERK and blocking VEGFR-2 signaling. It also reduces Pseudomonas aeruginosa internalization in human pneumocyte models [1][4]. |
| In vivo | In vivo, supplementing mouse diets with 5% 6'-Sialyllactose for 2 weeks significantly diminishes stressor-induced anxiety-like behavior and maintains the number of DCX-positive cells in the hippocampus [2]. In muscle health studies, oral administration of 6'-SL (100 mg/kg, 12 weeks) increases muscle mass and strength, leading to improved exercise endurance [3]. Furthermore, it effectively ameliorates benign prostatic hyperplasia in mice by suppressing angiogenesis [4] |
| Molecular Weight | 633.55 |
| Formula | C23H39NO19 |
| Cas No. | 35890-39-2 |
| Smiles | O(C[C@H]1O[C@@H](O[C@@H]([C@@H]([C@H](C=O)O)O)[C@@H](CO)O)[C@H](O)[C@@H](O)[C@H]1O)[C@@]2(C(O)=O)O[C@@]([C@@H]([C@@H](CO)O)O)([C@H](NC(C)=O)[C@@H](O)C2)08 |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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