• Specifications

    Product Description

    Mouse recombinant monoclonal antibody raised against human Amyloid beta 4-10.Recombinant Antibody,Recombinant Antibodies,Recombinant Monoclonal Antibody,RecomAb,Recombinant Ab,Recombinant Monoclonal Antibodies,Recombinant Abs,RAB,MAB,Recombinant Mab,MAB,monoclonal Ab,monoclonal antibody

    Antibody Species

    Mouse

    Immunogen

    Original antibody is raised against a synthetic peptide of human Amyloid beta.

    Reactivity

    Human

    Specificity

    This antibody recognizes acid residues 4-10 of human Amyloid beta.

    Form

    Liquid

    Preparation Method

    Mammalian cell (HEK293) expression system

    Purification

    Protein A affinity purification

    Isotype

    IgG2a, kappa

    Recommend Usage

    ELISA (0.1 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
    Western Blot (1 ug/mL)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS, pH 7.2 (0.02% Proclin 300)

    Storage Instruction

    Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.

  • Applications

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Enzyme-linked Immunoabsorbent Assay

    Western Blot

  • Gene Info — APP

    Entrez GeneID

    351

    Protein Accession#

    P05067

    Gene Name

    APP

    Gene Alias

    AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2

    Gene Description

    amyloid beta (A4) precursor protein

    Omim ID

    104760 605714

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq

    Other Designations

    A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|peptidase nexin-II|protease nexin-II

  • Interactomes
  • Diseases

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