Anti-DKK1 Antibody (4K388)
Referência NB-64-120040-50uL
Tamanho : 50uL
Marca : Neo Biotech
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Anti-DKK1 Antibody (4K388)
(Synonyms: SK, hDkk-1, hDkk1, Dkk-1, Dkk1, Dickkopf-related 1, Dickkopf-1) Copy Product InfoSynonyms: SK, hDkk-1, hDkk1, Dkk-1, Dkk1, Dickkopf-related 1, Dickkopf-1
Catalog No. TMAH-00348 Copy Product Info
Anti-DKK1 Antibody (4K388) is an antibody targeting DKK1. Anti-DKK1 Antibody (4K388) can be used in ELISA,WB.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Information
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-DKK1 Antibody (4K388) is an antibody targeting DKK1. Anti-DKK1 Antibody (4K388) can be used in ELISA,WB. |
| Synonyms | SK, hDkk-1, hDkk1, Dkk-1, Dkk1, Dickkopf-related 1, Dickkopf-1 |
| Ig Type | Rabbit IgG |
| Clone | 4K388 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: 293 whole cell lysate -All lanes: DKK1 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 29 kDa -Observed band size: 38 kDa |
| Application | ELISA WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Placenta. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human DKK1 |
| Antigen Species | Human |
| Gene Name | DKK1 |
| Gene ID | 22943 |
| Uniprot ID | O94907 |
| Biology Area | Cardiovascular, Developmental biology, Immunology, Stem cells |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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